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TargetGonadotropin-releasing hormone receptor
LigandBDBM50085722
Substrate/Competitorn/a
Meas. Tech.ChEMBL_71750 (CHEMBL680272)
Ki 0.35±n/a nM
Citation Rivier, JEStruthers, RSPorter, JLahrichi, SLJiang, GCervini, LAIbea, MKirby, DAKoerber, SCRivier, CL Design of potent dicyclic (4-10/5-8) gonadotropin releasing hormone (GnRH) antagonists. J Med Chem43:784-96 (2000) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Gonadotropin-releasing hormone receptor
Name:Gonadotropin-releasing hormone receptor
Synonyms:GNRHR_RAT | GnRH receptor | GnRH-R | Gnrhr
Type:PROTEIN
Mol. Mass.:37767.60
Organism:Rattus norvegicus
Description:ChEMBL_1335047
Residue:327
Sequence:
MANNASLEQDQNHCSAINNSIPLTQGKLPTLTLSGKIRVTVTFFLFLLSTAFNASFLVKL
QRWTQKRKKGKKLSRMKVLLKHLTLANLLETLIVMPLDGMWNITVQWYAGEFLCKVLSYL
KLFSMYAPAFMMVVISLDRSLAVTQPLAVQSKSKLERSMTSLAWILSIVFAGPQLYIFRM
IYLADGSGPAVFSQCVTHCSFPQWWHEAFYNFFTFSCLFIIPLLIMLICNAKIIFALTRV
LHQDPRKLQLNQSKNNIPRARLRTLKMTVAFGTSFVICWTPYYVLGIWYWFDPEMLNRVS
EPVNHFFFLFAFLNPCFDPLIYGYFSL
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50085722
n/a
NameBDBM50085722
Synonyms:CHEMBL413896 | DiCyclo (4-10/5,5'-8) [Ac-D Nal, D Cpa, D Pal, Asp, Asp(Gly), D Arg, Leu, Dbu, Pro, Dpr]GnRH
TypeSmall organic molecule
Emp. Form.C57H81ClN18O14
Mol. Mass.1277.818
SMILESCC[C@H](NC(C)=O)C(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1cccnc1)C(=O)N[C@@H]1CC(=O)NCC(NC(=O)[C@H]2CCCN2C(=O)C2CCNC(=O)CNC(=O)C[C@@H](NC1=O)C(=O)N[C@H](CCCNC(N)=N)C(=O)N[C@H](CC(C)C)C(=O)N2)C(N)=O
Structure
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