| Reaction Details |
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 | Report a problem with these data |
| Target | Gonadotropin-releasing hormone receptor |
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| Ligand | BDBM50085761 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_71751 (CHEMBL680273) |
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| Ki | 0.18±n/a nM |
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| Citation |  Rivier, JE; Porter, J; Cervini, LA; Lahrichi, SL; Kirby, DA; Struthers, RS; Koerber, SC; Rivier, CL Design of monocyclic (1-3) and dicyclic (1-3/4-10) gonadotropin releasing hormone (GnRH) antagonists. J Med Chem43:797-806 (2000) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Gonadotropin-releasing hormone receptor |
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| Name: | Gonadotropin-releasing hormone receptor |
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| Synonyms: | GNRHR_RAT | GnRH receptor | GnRH-R | Gnrhr |
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| Type: | PROTEIN |
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| Mol. Mass.: | 37767.60 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_1335047 |
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| Residue: | 327 |
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| Sequence: | MANNASLEQDQNHCSAINNSIPLTQGKLPTLTLSGKIRVTVTFFLFLLSTAFNASFLVKL
QRWTQKRKKGKKLSRMKVLLKHLTLANLLETLIVMPLDGMWNITVQWYAGEFLCKVLSYL
KLFSMYAPAFMMVVISLDRSLAVTQPLAVQSKSKLERSMTSLAWILSIVFAGPQLYIFRM
IYLADGSGPAVFSQCVTHCSFPQWWHEAFYNFFTFSCLFIIPLLIMLICNAKIIFALTRV
LHQDPRKLQLNQSKNNIPRARLRTLKMTVAFGTSFVICWTPYYVLGIWYWFDPEMLNRVS
EPVNHFFFLFAFLNPCFDPLIYGYFSL
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| BDBM50085761 |
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| n/a |
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| Name | BDBM50085761 |
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| Synonyms: | CHEMBL437038 | cyclo(1,1'-3)Ac-D-Asp (Gaba)-D-Cpa-D-Dpr-Ser-Tyr-D-Nal-Leu-Arg-Pro-D-Ala-NH2 |
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| Type | Small organic molecule |
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| Emp. Form. | C67H89ClN16O15 |
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| Mol. Mass. | 1393.975 |
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| SMILES | CC(C)C[C@@H](NC(=O)C(Cc1ccc2ccccc2c1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H]1CNC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)C(CC(=O)NCCCC(=O)N1)NC(C)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@@H]1C(=O)NC(C)C(N)=O |
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| Structure | 
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