| Reaction Details |
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 | Report a problem with these data |
| Target | Gonadotropin-releasing hormone receptor |
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| Ligand | BDBM50085815 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_71869 (CHEMBL877834) |
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| Ki | 0.27±n/a nM |
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| Citation |  Koerber, SC; Rizo, J; Struthers, RS; Rivier, JE Consensus bioactive conformation of cyclic GnRH antagonists defined by NMR and molecular modeling. J Med Chem43:819-28 (2000) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Gonadotropin-releasing hormone receptor |
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| Name: | Gonadotropin-releasing hormone receptor |
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| Synonyms: | GNRHR | GNRHR_HUMAN | GRHR | GnRH receptor | GnRH-R | Gonadotropin releasing hormone 1 (GnRHR1) | Gonadotropin-releasing hormone receptor | Gonadotropin-releasing hormone receptor (GnRH) |
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| Type: | Enzyme |
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| Mol. Mass.: | 37749.45 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P30968 |
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| Residue: | 328 |
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| Sequence: | MANSASPEQNQNHCSAINNSIPLMQGNLPTLTLSGKIRVTVTFFLFLLSATFNASFLLKL
QKWTQKKEKGKKLSRMKLLLKHLTLANLLETLIVMPLDGMWNITVQWYAGELLCKVLSYL
KLFSMYAPAFMMVVISLDRSLAITRPLALKSNSKVGQSMVGLAWILSSVFAGPQLYIFRM
IHLADSSGQTKVFSQCVTHCSFSQWWHQAFYNFFTFSCLFIIPLFIMLICNAKIIFTLTR
VLHQDPHELQLNQSKNNIPRARLKTLKMTVAFATSFTVCWTPYYVLGIWYWFDPEMLNRL
SDPVNHFFFLFAFLNPCFDPLIYGYFSL
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| BDBM50085815 |
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| n/a |
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| Name | BDBM50085815 |
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| Synonyms: | CHEMBL269726 | cyclo(4-10)[Ac-3Pro-DFpa-DTrp-c[Asp-Tyr-D2Nal-Leu-Arg-Pro-Dpr-NH2] |
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| Type | Small organic molecule |
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| Emp. Form. | C73H87FN16O13 |
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| Mol. Mass. | 1415.5697 |
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| SMILES | CC(C)C[C@@H]1NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CC(=O)NC[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@@H](CCCNC(N)=N)NC1=O)C(N)=O)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1ccc(F)cc1)NC(=O)[C@H]1C=CCN1C(C)=O |c:104| |
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| Structure | 
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