| Reaction Details |
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 | Report a problem with these data |
| Target | Cytosolic phospholipase A2 |
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| Ligand | BDBM50085984 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_217519 (CHEMBL820842) |
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| IC50 | 2.1±n/a nM |
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| Citation |  Seno, K; Okuno, T; Nishi, K; Murakami, Y; Watanabe, F; Matsuura, T; Wada, M; Fujii, Y; Yamada, M; Ogawa, T; Okada, T; Hashizume, H; Kii, M; Hara, S; Hagishita, S; Nakamoto, S; Yamada, K; Chikazawa, Y; Ueno, M; Teshirogi, I; Ono, T; Ohtani, M Pyrrolidine inhibitors of human cytosolic phospholipase A(2). J Med Chem43:1041-4 (2000) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Cytosolic phospholipase A2 |
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| Name: | Cytosolic phospholipase A2 |
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| Synonyms: | CPLA2 | Lysophospholipase | PA24A_HUMAN | PLA2G4 | PLA2G4A | Phosphatidylcholine 2-acylhydrolase | Phospholipase A2 | Phospholipase A2 group IVA |
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| Type: | Protein |
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| Mol. Mass.: | 85219.30 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P47712 |
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| Residue: | 749 |
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| Sequence: | MSFIDPYQHIIVEHQYSHKFTVVVLRATKVTKGAFGDMLDTPDPYVELFISTTPDSRKRT
RHFNNDINPVWNETFEFILDPNQENVLEITLMDANYVMDETLGTATFTVSSMKVGEKKEV
PFIFNQVTEMVLEMSLEVCSCPDLRFSMALCDQEKTFRQQRKEHIRESMKKLLGPKNSEG
LHSARDVPVVAILGSGGGFRAMVGFSGVMKALYESGILDCATYVAGLSGSTWYMSTLYSH
PDFPEKGPEEINEELMKNVSHNPLLLLTPQKVKRYVESLWKKKSSGQPVTFTDIFGMLIG
ETLIHNRMNTTLSSLKEKVNTAQCPLPLFTCLHVKPDVSELMFADWVEFSPYEIGMAKYG
TFMAPDLFGSKFFMGTVVKKYEENPLHFLMGVWGSAFSILFNRVLGVSGSQSRGSTMEEE
LENITTKHIVSNDSSDSDDESHEPKGTENEDAGSDYQSDNQASWIHRMIMALVSDSALFN
TREGRAGKVHNFMLGLNLNTSYPLSPLSDFATQDSFDDDELDAAVADPDEFERIYEPLDV
KSKKIHVVDSGLTFNLPYPLILRPQRGVDLIISFDFSARPSDSSPPFKELLLAEKWAKMN
KLPFPKIDPYVFDREGLKECYVFKPKNPDMEKDCPTIIHFVLANINFRKYRAPGVPRETE
EEKEIADFDIFDDPESPFSTFNFQYPNQAFKRLHDLMHFNTLNNIDVIKEAMVESIEYRR
QNPSRCSVSLSNVEARRFFNKEFLSKPKA
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| BDBM50085984 |
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| n/a |
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| Name | BDBM50085984 |
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| Synonyms: | CHEMBL9161 | N-[1-[2-(2,4-Difluoro-benzoyl)-benzoyl]-4-(3-isobutyl-2'-isopropyl-biphenyl-2-yloxy)-pyrrolidin-2-ylmethyl]-4-(2,4-dioxo-thiazolidin-5-ylidenemethyl)-benzamide |
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| Type | Small organic molecule |
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| Emp. Form. | C49H45F2N3O6S |
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| Mol. Mass. | 841.96 |
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| SMILES | CC(C)Cc1cccc(c1O[C@@H]1C[C@@H](CNC(=O)c2ccc(C=C3SC(O)=NC3=O)cc2)N(C1)C(=O)c1ccccc1C(=O)c1ccc(F)cc1F)-c1ccccc1C(C)C |w:22.22,c:27| |
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| Structure | 
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