Reaction Details |
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Target | 5-hydroxytryptamine receptor 1A |
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Ligand | BDBM50086853 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_1229 |
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Ki | 190±n/a nM |
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Citation | Fujio, M; Togo, Y; Tomozane, H; Kuroita, T; Morio, Y; Katayama, J; Matsumoto, Y N-[[1-(2-phenylethyl)pyrrolidin-2-yl]methyl]cyclohexanecarboxamides as selective 5-HT1A receptor agonists. Bioorg Med Chem Lett10:509-12 (2000) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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5-hydroxytryptamine receptor 1A |
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Name: | 5-hydroxytryptamine receptor 1A |
Synonyms: | 5-HT-1A | 5-HT1 | 5-HT1A | 5-Hydroxytryptamine receptor 1A (5-HT1A) | 5-hydroxytryptamine receptor 1A (5HT1A) | 5HT1A_RAT | 5ht1a | G-21 | Htr1a | Serotonin 1 (5-HT1) receptor | Serotonin 1a (5-HT1a) receptor/Adrenergic receptor alpha-1 | Serotonin receptor 1A |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 46445.29 |
Organism: | Rattus norvegicus (rat) |
Description: | Binding assays were performed using rat hippocampal membranes. |
Residue: | 422 |
Sequence: | MDVFSFGQGNNTTASQEPFGTGGNVTSISDVTFSYQVITSLLLGTLIFCAVLGNACVVAA
IALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCC
TSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPED
RSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVRKVEKKGAGT
SLGTSSAPPPKKSLNGQPGSGDWRRCAENRAVGTPCTNGAVRQGDDEATLEVIEVHRVGN
SKEHLPLPSESGSNSYAPACLERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLP
FFIVALVLPFCESSCHMPALLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFC
RR
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BDBM50086853 |
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n/a |
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Name | BDBM50086853 |
Synonyms: | CHEMBL82652 | Cyclohexanecarboxylic acid ((R)-1-phenethyl-pyrrolidin-2-ylmethyl)-amide |
Type | Small organic molecule |
Emp. Form. | C20H30N2O |
Mol. Mass. | 314.465 |
SMILES | O=C(NC[C@H]1CCCN1CCc1ccccc1)C1CCCCC1 |
Structure |
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