| Reaction Details |
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 | Report a problem with these data |
| Target | Alpha-2A adrenergic receptor [16-465] |
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| Ligand | BDBM50085678 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_33684 (CHEMBL647841) |
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| Ki | 0.56±n/a nM |
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| Citation |  Ross, TM; Jetter, MC; McDonnell, ME; Boyd, RE; Connelly, CD; Martinez, RP; Lewis, MA; Codd, EE; Raffa, RB; Reitz, AB Alpha(2) adrenoceptor agonists as potential analgesic agents. 2. Discovery of 4-(4-imidazo)-1,3-dimethyl-6,7-dihydro-thianaphthene as a high-affinity ligand for the alpha(2D) adrenergic receptor. J Med Chem43:1423-6 (2001) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Alpha-2A adrenergic receptor [16-465] |
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| Name: | Alpha-2A adrenergic receptor [16-465] |
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| Synonyms: | ADA2A_RAT | Adra2a | Adrenaline 2 | Alpha-2A adrenergic receptor | Alpha-2A adrenoceptor | Alpha-2A adrenoreceptor | Alpha-2AAR | Alpha-2D adrenergic receptor | Alpha2 Adrenoreceptor | CA2-47 | adrenergic Alpha2A |
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| Type: | G-protein coupled receptor |
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| Mol. Mass.: | 48961.69 |
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| Organism: | Rattus norvegicus (rat) |
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| Description: | P22909[16-465] |
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| Residue: | 450 |
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| Sequence: | MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFT
SRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSS
IVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGG
QQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACS
APPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSE
HAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKAS
RWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSS
LNPVIYTIFNHDFRRAFKKILCRGDRKRIV
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| BDBM50085678 |
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| n/a |
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| Name | BDBM50085678 |
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| Synonyms: | 4-(4,5,6,7-Tetrahydro-benzo[b]thiophen-4-yl)-1H-imidazole | CHEMBL284213 |
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| Type | Small organic molecule |
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| Emp. Form. | C11H12N2S |
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| Mol. Mass. | 204.291 |
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| SMILES | C1CC(c2cnc[nH]2)c2ccsc2C1 |
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| Structure | 
|
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