| Reaction Details |
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 | Report a problem with these data |
| Target | Coagulation factor X |
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| Ligand | BDBM50087538 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_48820 |
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| Ki | 0.550000±n/a nM |
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| Citation |  Pruitt, JR; Pinto, DJ; Estrella, MJ; Bostrom, LL; Knabb, RM; Wong, PC; Wright, MR; Wexler, RR Isoxazolines and isoxazoles as factor Xa inhibitors. Bioorg Med Chem Lett10:685-9 (2000) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Coagulation factor X |
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| Name: | Coagulation factor X |
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| Synonyms: | Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | FA10_HUMAN | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor |
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| Type: | Enzyme |
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| Mol. Mass.: | 54726.60 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 488 |
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| Sequence: | MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEE
TCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKN
CELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERR
KRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQE
CKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGE
AVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGI
VSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSG
GPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPE
VITSSPLK
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| BDBM50087538 |
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| n/a |
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| Name | BDBM50087538 |
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| Synonyms: | (4S,5S)-3-(3-Carbamimidoyl-phenyl)-5-methoxymethyl-4,5-dihydro-isoxazole-4-carboxylic acid (2'-sulfamoyl-biphenyl-4-yl)-amide | CHEMBL351688 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H25N5O5S |
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| Mol. Mass. | 507.562 |
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| SMILES | COC[C@H]1ON=C([C@@H]1C(=O)Nc1ccc(cc1)-c1ccccc1S(N)(=O)=O)c1cccc(c1)C(N)=N |c:5| |
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| Structure | 
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