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TargetCoagulation factor X
LigandBDBM50087536
Substrate/Competitorn/a
Meas. Tech.ChEBML_48820
Ki 0.100000±n/a nM
Citation Pruitt JRPinto DJEstrella MJBostrom LLKnabb RMWong PCWright MRWexler RR Isoxazolines and isoxazoles as factor Xa inhibitors. Bioorg Med Chem Lett 10:685-9 (2000) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Coagulation factor X
Name:Thrombin and coagulation factor X
Synonyms:Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor
Type:Enzyme
Mol. Mass.:54726.60
Organism:Homo sapiens (Human)
Description:n/a
Residue:488
Sequence:
MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEE
TCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKN
CELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERR
KRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQE
CKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGE
AVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGI
VSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSG
GPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPE
VITSSPLK
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  Blast E-value cutoff:
BDBM50087536
n/a
NameBDBM50087536
Synonyms:3-(3-Carbamimidoyl-phenyl)-isoxazole-4-carboxylic acid (2'-methanesulfonyl-biphenyl-4-yl)-amide | CHEMBL159816
TypeSmall organic molecule
Emp. Form.C24H20N4O4S
Mol. Mass.460.505
SMILESCS(=O)(=O)c1ccccc1-c1ccc(NC(=O)c2conc2-c2cccc(c2)C(N)=N)cc1
Structure
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