Reaction Details | |||
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Target | Corticotropin-releasing factor receptor 1 | ||
Ligand | BDBM50087556 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEBML_51284 | ||
Ki | 0.910000±n/a nM | ||
Citation | Hsin, LW; Webster, EL; Chrousos, GP; Gold, PW; Eckelman, WC; Contoreggi, C; Rice, KC Synthesis and biological activity of fluoro-substituted pyrrolo[2,3-d]pyrimidines: the development of potential positron emission tomography imaging agents for the corticotropin-releasing hormone type 1 receptor. Bioorg Med Chem Lett10:707-10 (2000) [PubMed] | ||
More Info.: | Get all data from this article, Assay Method | ||
Corticotropin-releasing factor receptor 1 | |||
Name: | Corticotropin-releasing factor receptor 1 | ||
Synonyms: | CRF-R | CRF1 | CRFR1_RAT | CRH-R 1 | Corticotropin releasing factor receptor | Corticotropin releasing factor receptor 1 | Corticotropin-releasing Factor Receptor 1 | Corticotropin-releasing hormone receptor 1 | Crhr | Crhr1 | ||
Type: | G Protein-Coupled Receptor (GPCR) | ||
Mol. Mass.: | 47870.75 | ||
Organism: | Rattus norvegicus (rat) | ||
Description: | Receptor binding assays were performed using rat cortex homogenate. | ||
Residue: | 415 | ||
Sequence: |
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BDBM50087556 | |||
n/a | |||
Name | BDBM50087556 | ||
Synonyms: | (4-Fluoro-butyl)-propyl-[2,5,6-trimethyl-7-(2,4,6-trimethyl-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-amine | CHEMBL434882 | ||
Type | Small organic molecule | ||
Emp. Form. | C25H35FN4 | ||
Mol. Mass. | 410.5706 | ||
SMILES | CCCN(CCCCF)c1nc(C)nc2n(c(C)c(C)c12)-c1c(C)cc(C)cc1C |(7.65,-.09,;7.16,-1.55,;8.19,-2.71,;7.72,-4.17,;6.2,-4.5,;5.18,-3.35,;3.67,-3.67,;2.64,-2.53,;1.13,-2.84,;8.75,-5.32,;8.28,-6.79,;9.31,-7.93,;8.85,-9.41,;10.81,-7.61,;11.29,-6.15,;12.7,-5.53,;12.54,-3.98,;13.69,-2.95,;11.02,-3.67,;10.4,-2.25,;10.26,-5,;14.04,-6.29,;14.04,-7.84,;12.7,-8.61,;15.37,-8.61,;16.7,-7.84,;18.05,-8.61,;16.7,-6.29,;15.37,-5.52,;15.36,-3.97,)| | ||
Structure |