Reaction Details |
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Target | Mu-type opioid receptor |
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Ligand | BDBM50088361 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_148995 (CHEMBL757979) |
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Ki | 10±n/a nM |
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Citation | Vianello, P; Albinati, A; Pinna, GA; Lavecchia, A; Marinelli, L; Borea, PA; Gessi, S; Fadda, P; Tronci, S; Cignarella, G Synthesis, molecular modeling, and opioid receptor affinity of 9, 10-diazatricyclo[4.2.1.1(2,5)]decanes and 2,7-diazatricyclo[4.4.0. 0(3,8)]decanes structurally related to 3,8-diazabicyclo[3.2. 1]octanes. J Med Chem43:2115-23 (2000) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Mu-type opioid receptor |
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Name: | Mu-type opioid receptor |
Synonyms: | MOR-1 | MUOR1 | Mu-type opioid receptor (MOR) | OPIATE Mu | OPRM_RAT | Opiate non-selective | Opioid receptor B | Oprm1 | Ror-b |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 44503.11 |
Organism: | Rattus norvegicus (rat) |
Description: | Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the mu opioid receptor. |
Residue: | 398 |
Sequence: | MDSSTGPGNTSDCSDPLAQASCSPAPGSWLNLSHVDGNQSDPCGLNRTGLGGNDSLCPQT
GSPSMVTAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATST
LPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRT
PRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFA
FIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYV
IIKALITIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSTIEQ
QNSTRVRQNTREHPSTANTVDRTNHQLENLEAETAPLP
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BDBM50088361 |
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n/a |
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Name | BDBM50088361 |
Synonyms: | 1-{10-[3-(3-Nitro-phenyl)-allyl]-9,10-diaza-tricyclo[4.2.1.1*2,5*]dec-9-yl}-propan-1-one | CHEMBL67384 |
Type | Small organic molecule |
Emp. Form. | C20H25N3O3 |
Mol. Mass. | 355.4308 |
SMILES | CCC(=O)N1C2CC[C@H]1[C@@H]1CCC2N1C\C=C\c1cccc(c1)[N+]([O-])=O |TLB:2:4:13:10.11,10:9:4:6.7,11:12:4:6.7,THB:14:13:4.5.8:10.11,14:13:4:6.7,6:5:13:10.11,7:8:13:10.11| |
Structure |
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