Reaction Details |
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Target | 5-hydroxytryptamine receptor 1A |
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Ligand | BDBM50056362 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_1153 |
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Ki | 3.7±n/a nM |
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Citation | Modica, M; Santagati, M; Santagati, A; Russo, F; Cagnotto, A; Goegan, M; Mennini, T High potent and selective arylpiperazine derivatives as ligands for the 5-HT1A receptor. Bioorg Med Chem Lett10:1089-92 (2000) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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5-hydroxytryptamine receptor 1A |
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Name: | 5-hydroxytryptamine receptor 1A |
Synonyms: | 5-HT-1A | 5-HT1 | 5-HT1A | 5-Hydroxytryptamine receptor 1A (5-HT1A) | 5-hydroxytryptamine receptor 1A (5HT1A) | 5HT1A_RAT | 5ht1a | G-21 | Htr1a | Serotonin 1 (5-HT1) receptor | Serotonin 1a (5-HT1a) receptor/Adrenergic receptor alpha-1 | Serotonin receptor 1A |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 46445.29 |
Organism: | Rattus norvegicus (rat) |
Description: | Binding assays were performed using rat hippocampal membranes. |
Residue: | 422 |
Sequence: | MDVFSFGQGNNTTASQEPFGTGGNVTSISDVTFSYQVITSLLLGTLIFCAVLGNACVVAA
IALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCC
TSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPED
RSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVRKVEKKGAGT
SLGTSSAPPPKKSLNGQPGSGDWRRCAENRAVGTPCTNGAVRQGDDEATLEVIEVHRVGN
SKEHLPLPSESGSNSYAPACLERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLP
FFIVALVLPFCESSCHMPALLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFC
RR
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BDBM50056362 |
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n/a |
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Name | BDBM50056362 |
Synonyms: | 3-Amino-5,6-dimethyl-2-[3-(4-pyrimidin-2-yl-piperazin-1-yl)-propylsulfanyl]-3H-thieno[2,3-d]pyrimidin-4-one | CHEMBL12177 |
Type | Small organic molecule |
Emp. Form. | C19H25N7OS2 |
Mol. Mass. | 431.578 |
SMILES | Cc1sc2nc(SCCCN3CCN(CC3)c3ncccn3)n(N)c(=O)c2c1C |
Structure |
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