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TargetAcetylcholine receptor subunit alpha/beta/delta/gamma
LigandBDBM50089157
Substrate/Competitorn/a
Meas. Tech.ChEMBL_144964 (CHEMBL755082)
Ki 50000±n/a nM
Citation Takahata, HTakahashi, SAzer, NEldefrawi, ATEldefrawi, ME Total synthesis of pyrrolizidines 223H', 239K', 265H', and 267H' found in Madagascan frogs (Mantella) and their affinities for nicotinic acetylcholine receptor. Bioorg Med Chem Lett10:1293-5 (2000) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Acetylcholine receptor subunit alpha/beta/delta/gamma
Name:Acetylcholine receptor subunit alpha/beta/delta/gamma
Synonyms:Acetylcholine receptor | Acetylcholine receptor protein alpha/beta/delta/gamma chain
Type:n/a
Mol. Mass.:n/a
Description:ASSAY_ID of EBI is 143080
Components:This complex has 4 components.
Component 1
Name:Acetylcholine receptor subunit beta
Synonyms:ACHB_TETCF | Acetylcholine receptor | CHRNB1
Type:PROTEIN
Mol. Mass.:56146.98
Organism:Torpedo californica
Description:EBI_19626
Residue:493
Sequence:
MENVRRMALGLVVMMALALSGVGASVMEDTLLSVLFETYNPKVRPAQTVGDKVTVRVGLT
LTNLLILNEKIEEMTTNVFLNLAWTDYRLQWDPAAYEGIKDLRIPSSDVWQPDIVLMNNN
DGSFEITLHVNVLVQHTGAVSWQPSAIYRSSCTIKVMYFPFDWQNCTMVFKSYTYDTSEV
TLQHALDAKGEREVKEIVINKDAFTENGQWSIEHKPSRKNWRSDDPSYEDVTFYLIIQRK
PLFYIVYTIIPCILISILAILVFYLPPDAGEKMSLSISALLAVTVFLLLLADKVPETSLS
VPIIIRYLMFIMILVAFSVILSVVVLNLHHRSPNTHTMPNWIRQIFIETLPPFLWIQRPV
TTPSPDSKPTIISRANDEYFIRKPAGDFVCPVDNARVAVQPERLFSEMKWHLNGLTQPVT
LPQDLKEAVEAIKYIAEQLESASEFDDLKKDWQYVAMVADRLFLYVFFVICSIGTFSIFL
DASHNVPPDNPFA
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Component 2
Name:Acetylcholine receptor subunit gamma
Synonyms:ACHG_TETCF | Acetylcholine receptor | CHRNG
Type:PROTEIN
Mol. Mass.:58151.68
Organism:Torpedo californica
Description:EBI_19662
Residue:506
Sequence:
MVLTLLLIICLALEVRSENEEGRLIEKLLGDYDKRIIPAKTLDHIIDVTLKLTLTNLISL
NEKEEALTTNVWIEIQWNDYRLSWNTSEYEGIDLVRIPSELLWLPDVVLENNVDGQFEVA
YYANVLVYNDGSMYWLPPAIYRSTCPIAVTYFPFDWQNCSLVFRSQTYNAHEVNLQLSAE
EGEAVEWIHIDPEDFTENGEWTIRHRPAKKNYNWQLTKDDTDFQEIIFFLIIQRKPLFYI
INIIAPCVLISSLVVLVYFLPAQAGGQKCTLSISVLLAQTIFLFLIAQKVPETSLNVPLI
GKYLIFVMFVSMLIVMNCVIVLNVSLRTPNTHSLSEKIKHLFLGFLPKYLGMQLEPSEET
PEKPQPRRRSSFGIMIKAEEYILKKPRSELMFEEQKDRHGLKRVNKMTSDIDIGTTVDLY
KDLANFAPEIKSCVEACNFIAKSTKEQNDSGSENENWVLIGKVIDKACFWIALLLFSIGT
LAIFLTGHFNQVPEFPFPGDPRKYVP
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Component 3
Name:Acetylcholine receptor subunit alpha
Synonyms:ACHA_TETCF | Acetylcholine receptor | Acetylcholine receptor protein alpha chain | CHRNA1
Type:PROTEIN
Mol. Mass.:52735.09
Organism:Torpedo californica
Description:ChEMBL_216981
Residue:461
Sequence:
MILCSYWHVGLVLLLFSCCGLVLGSEHETRLVANLLENYNKVIRPVEHHTHFVDITVGLQ
LIQLISVDEVNQIVETNVRLRQQWIDVRLRWNPADYGGIKKIRLPSDDVWLPDLVLYNNA
DGDFAIVHMTKLLLDYTGKIMWTPPAIFKSYCEIIVTHFPFDQQNCTMKLGIWTYDGTKV
SISPESDRPDLSTFMESGEWVMKDYRGWKHWVYYTCCPDTPYLDITYHFIMQRIPLYFVV
NVIIPCLLFSFLTGLVFYLPTDSGEKMTLSISVLLSLTVFLLVIVELIPSTSSAVPLIGK
YMLFTMIFVISSIIITVVVINTHHRSPSTHTMPQWVRKIFIDTIPNVMFFSTMKRASKEK
QENKIFADDIDISDISGKQVTGEVIFQTPLIKNPDVKSAIEGVKYIAEHMKSDEESSNAA
EEWKYVAMVIDHILLCVFMLICIIGTVSVFAGRLIELSQEG
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Component 4
Name:Acetylcholine receptor subunit delta
Synonyms:ACHD_TETCF | Acetylcholine receptor | Acetylcholine receptor protein delta chain | chrnd
Type:PROTEIN
Mol. Mass.:59885.01
Organism:Torpedo californica
Description:ChEMBL_142744
Residue:522
Sequence:
MGNIHFVYLLISCLYYSGCSGVNEEERLINDLLIVNKYNKHVRPVKHNNEVVNIALSLTL
SNLISLKETDETLTSNVWMDHAWYDHRLTWNASEYSDISILRLPPELVWIPDIVLQNNND
GQYHVAYFCNVLVRPNGYVTWLPPAIFRSSCPINVLYFPFDWQNCSLKFTALNYDANEIT
MDLMTDTIDGKDYPIEWIIIDPEAFTENGEWEIIHKPAKKNIYPDKFPNGTNYQDVTFYL
IIRRKPLFYVINFITPCVLISFLASLAFYLPAESGEKMSTAISVLLAQAVFLLLTSQRLP
ETALAVPLIGKYLMFIMSLVTGVIVNCGIVLNFHFRTPSTHVLSTRVKQIFLEKLPRILH
MSRADESEQPDWQNDLKLRRSSSVGYISKAQEYFNIKSRSELMFEKQSERHGLVPRVTPR
IGFGNNNENIAASDQLHDEIKSGIDSTNYIVKQIKEKNAYDEEVGNWNLVGQTIDRLSMF
IITPVMVLGTIFIFVMGNFNHPPAKPFEGDPFDYSSDHPRCA
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BDBM50089157
n/a
NameBDBM50089157
Synonyms:(3R,5S,7aR)-3-Heptyl-5-methyl-hexahydro-pyrrolizine | CHEMBL24149
TypeSmall organic molecule
Emp. Form.C15H29N
Mol. Mass.223.3975
SMILESCCCCCCC[C@@H]1CC[C@H]2CC[C@H](C)N12
Structure
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