Reaction Details |
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Target | Aldo-keto reductase family 1 member B1 |
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Ligand | BDBM16512 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_32102 (CHEMBL644303) |
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IC50 | 35±n/a nM |
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Citation | Oka, M; Matsumoto, Y; Sugiyama, S; Tsuruta, N; Matsushima, M A potent aldose reductase inhibitor, (2S,4S)-6-fluoro-2', 5'-dioxospiro[chroman-4,4'-imidazolidine]-2-carboxamide (Fidarestat): its absolute configuration and interactions with the aldose reductase by X-ray crystallography. J Med Chem43:2479-83 (2000) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Aldo-keto reductase family 1 member B1 |
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Name: | Aldo-keto reductase family 1 member B1 |
Synonyms: | ALDR_RAT | Akr1b1 | Akr1b4 | Aldose reductase | Aldr1 |
Type: | PROTEIN |
Mol. Mass.: | 35797.87 |
Organism: | Rattus norvegicus |
Description: | ChEMBL_1512484 |
Residue: | 316 |
Sequence: | MASHLELNNGTKMPTLGLGTWKSPPGQVTEAVKVAIDMGYRHIDCAQVYQNEKEVGVALQ
EKLKEQVVKRQDLFIVSKLWCTFHDQSMVKGACQKTLSDLQLDYLDLYLIHWPTGFKPGP
DYFPLDASGNVIPSDTDFVDTWTAMEQLVDEGLVKAIGVSNFNPLQIERILNKPGLKYKP
AVNQIECHPYLTQEKLIEYCHCKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKEIAAK
YNKTTAQVLIRFPIQRNLVVIPKSVTPARIAENFKVFDFELSNEDMATLLSYNRNWRVCA
LMSCAKHKDYPFHAEV
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BDBM16512 |
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n/a |
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Name | BDBM16512 |
Synonyms: | (2S,4S)-6-fluoro-2',5'-dioxo-2,3-dihydrospiro[1-benzopyran-4,4'-imidazolidine]-2-carboxamide | (2S,4S)-6-fluoro-2,5-dioxo-2,3-dihydrospiro[chromene-4,4-imidazolidine]-2-carboxamide | CHEMBL84446 | Fidarestat | Fidarestat (1) |
Type | Small organic molecule |
Emp. Form. | C12H10FN3O4 |
Mol. Mass. | 279.2239 |
SMILES | NC(=O)[C@@H]1C[C@]2(NC(=O)NC2=O)c2cc(F)ccc2O1 |r| |
Structure |
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