| Reaction Details |
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 | Report a problem with these data |
| Target | Chitin synthase 1 |
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| Ligand | BDBM50089562 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_49240 |
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| IC50 | 12±n/a nM |
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| Citation |  Masubuchi, K; Taniguchi, M; Umeda, I; Hattori, K; Suda, H; Kohchi, Y; Isshiki, Y; Sakai, T; Kohchi, M; Shirai, M; Okabe, H; Sudoh, M; Yamazaki, T; Shimma, N Synthesis and structure-activity relationships of novel fungal chitin synthase inhibitors. Bioorg Med Chem Lett10:1459-62 (2000) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Chitin synthase 1 |
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| Name: | Chitin synthase 1 |
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| Synonyms: | CHS1 | CHS1_CANAX | Chitin synthase | Chitin synthase 1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 88249.31 |
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| Organism: | Candida albicans |
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| Description: | ChEMBL_49240 |
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| Residue: | 776 |
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| Sequence: | MHNINNGYVPNREKTITKRKVRLVGGKAGNLVLENPVPTELRKVLTRTESPFGEFTNMTY
TACTSQPDTFSAEGFTLRAAKYGRETEIVICITMYNEDEVAFARTMHGVMKNIAHLCSRH
KSKIWGKDSWKKVQVIIVADGRNKVQQSVLELLTATGCYQENLARPYVNNSKVNAHLFEY
TTQISIDENLKFKGDEKNLAPVQVLFCLKESNQKKINSHRWLFNAFCPVLDPNVIVLLDV
GTKPDNHAIYNLWKAFDRDSNVAGAAGEIKAMKGKGWINLTNPLVASQNFEYKLSNILDK
PLESLFGYISVLPGALSAYRYIALKNHDDGTGPLASYFKGEDLLCSHDKDKENTKANFFE
ANMYLAEDRILCWELVSKRNDNWVLKFVKSATGETDVPETIAEFLSQRRRWINGAFFAAL
YSLYHFRKIWTTDHSYARKFWLHVEEFIYQLVSLLFSFFSLSNFYLTFYFLTGSLVSYKS
LGKKGGFWIFTLFNYLCIGVLTSLFIVSIGNRPHASKNIFKTLIILLTICALYALVVGFV
FVINTIATFGTGGTSTYVLVSIVVSLLSTYGLYTLMSILYLDPWHMLTCSVQYFLMIPSY
TCTLQIFAFCNTHDVSWGTKGDNNPKEDLSNQYIIEKNASGEFEAVIVDTNIDEDYLETL
YNIRSKRSNKKVALGHSEKTPLDGDDYAKDVRTRVVLFWMIANLVFIMTMVQVYEPGDTG
RNIYLAFILWAVAVLALVRAIGSLGYLIQTYARFFVESKSKWMKRGYTAPSHNPLN
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| BDBM50089562 |
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| n/a |
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| Name | BDBM50089562 |
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| Synonyms: | 3-Amino-5-[(6,6-dimethyl-hepta-2,4-diynyl)-methyl-amino]-3,4-dihydro-1H-quinolin-2-one | CHEMBL32780 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H23N3O |
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| Mol. Mass. | 309.4054 |
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| SMILES | CN(CC#CC#CC(C)(C)C)c1cccc2NC(=O)C(N)Cc12 |
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| Structure | 
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