| Reaction Details |
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 | Report a problem with these data |
| Target | 2-5A-dependent ribonuclease |
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| Ligand | BDBM50421415 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_195098 (CHEMBL800845) |
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| IC50 | 13±n/a nM |
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| Citation |  Wang, Z; Chen, L; Bayly, SF; Torrence, PF Convergent synthesis of ribonuclease L-active 2',5'-oligoadenylate-peptide nucleic acids. Bioorg Med Chem Lett10:1357-60 (2000) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| 2-5A-dependent ribonuclease |
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| Name: | 2-5A-dependent ribonuclease |
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| Synonyms: | 2-5A-dependent RNase | 2-5A-dependent ribonuclease | RN5A_HUMAN | RNASEL | RNS4 | RNase L | Ribonuclease 4 | Ribonuclease L |
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| Type: | PROTEIN |
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| Mol. Mass.: | 83534.35 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_164152 |
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| Residue: | 741 |
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| Sequence: | MESRDHNNPQEGPTSSSGRRAAVEDNHLLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGW
TPLHNAVQMSREDIVELLLRHGADPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVNE
CDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRRKTKEDQERLRKGGATALMDAAEKGH
VEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDVEAITHLLLDHGADVNVRGERGK
TPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTALLLAVELKLKKIAELLCKRGASTD
CGDLVMTARRNYDHSLVKVLLSHGAKEDFHPPAEDWKPQSSHWGAALKDLHRIYRPMIGK
LKFFIDEKYKIADTSEGGIYLGFYEKQEVAVKTFCEGSPRAQREVSCLQSSRENSHLVTF
YGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCG
YTHQDLQPQNILIDSKKAAHLADFDKSIKWAGDPQEVKRDLEDLGRLVLYVVKKGSISFE
DLKAQSNEEVVQLSPDEETKDLIHRLFHPGEHVRDCLSDLLGHPFFWTWESRYRTLRNVG
NESDIKTRKSESEILRLLQPGPSEHSKSFDKWTTKINECVMKKMNKFYEKRGNFYQNTVG
DLLKFIRNLGEHIDEEKHKKMKLKIGDPSLYFQKTFPDLVIYVYTKLQNTEYRKHFPQTH
SPNKPQCDGAGGASGLASPGC
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| BDBM50421415 |
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| n/a |
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| Name | BDBM50421415 |
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| Synonyms: | CHEMBL414948 |
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| Type | Small organic molecule |
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| Emp. Form. | C30H38N15O19P3 |
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| Mol. Mass. | 1005.6331 |
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| SMILES | Nc1ncnc2n(cnc12)[C@@H]1O[C@H](CO[P@](O)(=O)O[C@@H]2[C@H](O)[C@@H](CO[P@](O)(=O)O[C@@H]3[C@H](O)[C@@H](COP(O)(O)=O)O[C@H]3n3cnc4c(N)ncnc34)O[C@H]2n2cnc3c(N)ncnc23)[C@@H](O)[C@H]1O |r| |
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| Structure | 
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