Reaction Details |
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Target | 5-hydroxytryptamine receptor 1A |
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Ligand | BDBM50090759 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1206 (CHEMBL615972) |
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Ki | 14±n/a nM |
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Citation | Hammarberg, E; Nordvall, G; Leideborg, R; Nylöf, M; Hanson, S; Johansson, L; Thorberg, SO; Tolf, BR; Jerning, E; Svantesson, GT; Mohell, N; Ahlgren, C; Westlind-Danielsson, A; Csöregh, I; Johansson, R Synthesis of novel 5-substituted 3-amino-3,4-dihydro-2H-1-benzopyran derivatives and their interactions with the 5-HT1A receptor. J Med Chem43:2837-50 (2000) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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5-hydroxytryptamine receptor 1A |
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Name: | 5-hydroxytryptamine receptor 1A |
Synonyms: | 5-HT-1A | 5-HT1 | 5-HT1A | 5-Hydroxytryptamine receptor 1A (5-HT1A) | 5-hydroxytryptamine receptor 1A (5HT1A) | 5HT1A_RAT | 5ht1a | G-21 | Htr1a | Serotonin 1 (5-HT1) receptor | Serotonin 1a (5-HT1a) receptor/Adrenergic receptor alpha-1 | Serotonin receptor 1A |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 46445.29 |
Organism: | Rattus norvegicus (rat) |
Description: | Binding assays were performed using rat hippocampal membranes. |
Residue: | 422 |
Sequence: | MDVFSFGQGNNTTASQEPFGTGGNVTSISDVTFSYQVITSLLLGTLIFCAVLGNACVVAA
IALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCC
TSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPED
RSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVRKVEKKGAGT
SLGTSSAPPPKKSLNGQPGSGDWRRCAENRAVGTPCTNGAVRQGDDEATLEVIEVHRVGN
SKEHLPLPSESGSNSYAPACLERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLP
FFIVALVLPFCESSCHMPALLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFC
RR
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BDBM50090759 |
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n/a |
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Name | BDBM50090759 |
Synonyms: | (R)-3-Dipropylamino-chroman-5-carboxylic acid isopropylamide | (S)-3-Dipropylamino-chroman-5-carboxylic acid isopropylamide | CHEMBL95688 |
Type | Small organic molecule |
Emp. Form. | C19H30N2O2 |
Mol. Mass. | 318.4537 |
SMILES | CCCN(CCC)C1COc2cccc(C(=O)NC(C)C)c2C1 |
Structure |
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