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Target5-hydroxytryptamine receptor 1A
LigandBDBM50090771
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1206 (CHEMBL615972)
Ki 0.3±n/a nM
Citation Hammarberg, ENordvall, GLeideborg, RNylöf, MHanson, SJohansson, LThorberg, SOTolf, BRJerning, ESvantesson, GTMohell, NAhlgren, CWestlind-Danielsson, ACsöregh, IJohansson, R Synthesis of novel 5-substituted 3-amino-3,4-dihydro-2H-1-benzopyran derivatives and their interactions with the 5-HT1A receptor. J Med Chem43:2837-50 (2000) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
5-hydroxytryptamine receptor 1A
Name:5-hydroxytryptamine receptor 1A
Synonyms:5-HT-1A | 5-HT1 | 5-HT1A | 5-Hydroxytryptamine receptor 1A (5-HT1A) | 5-hydroxytryptamine receptor 1A (5HT1A) | 5HT1A_RAT | 5ht1a | G-21 | Htr1a | Serotonin 1 (5-HT1) receptor | Serotonin 1a (5-HT1a) receptor/Adrenergic receptor alpha-1 | Serotonin receptor 1A
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:46445.29
Organism:Rattus norvegicus (rat)
Description:Binding assays were performed using rat hippocampal membranes.
Residue:422
Sequence:
MDVFSFGQGNNTTASQEPFGTGGNVTSISDVTFSYQVITSLLLGTLIFCAVLGNACVVAA
IALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCC
TSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPED
RSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVRKVEKKGAGT
SLGTSSAPPPKKSLNGQPGSGDWRRCAENRAVGTPCTNGAVRQGDDEATLEVIEVHRVGN
SKEHLPLPSESGSNSYAPACLERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLP
FFIVALVLPFCESSCHMPALLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFC
RR
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50090771
n/a
NameBDBM50090771
Synonyms:(R)-1-[3-(Isopropyl-propyl-amino)-chroman-5-yl]-ethanone | (S)-1-[3-(Isopropyl-propyl-amino)-chroman-5-yl]-ethanone | CHEMBL97398
TypeSmall organic molecule
Emp. Form.C17H25NO2
Mol. Mass.275.3859
SMILESCCCN(C(C)C)C1COc2cccc(C(C)=O)c2C1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: