Reaction Details |
| Report a problem with these data |
Target | Endothelin-1 receptor |
---|
Ligand | BDBM50068742 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_65638 (CHEMBL681520) |
---|
Ki | 18±n/a nM |
---|
Citation | Murugesan, N; Gu, Z; Stein, PD; Spergel, S; Mathur, A; Leith, L; Liu, EC; Zhang, R; Bird, E; Waldron, T; Marino, A; Morrison, RA; Webb, ML; Moreland, S; Barrish, JC Biphenylsulfonamide endothelin receptor antagonists. 2. Discovery of 4'-oxazolyl biphenylsulfonamides as a new class of potent, highly selective ET(A) antagonists. J Med Chem43:3111-7 (2000) [PubMed] |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Endothelin-1 receptor |
---|
Name: | Endothelin-1 receptor |
Synonyms: | EDNRA | EDNRA_HUMAN | ET-A | ETA | ETA-R | ETRA | Endothelin receptor type A | Endothelin receptor, ET-A/ET-B | hET-AR |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 48736.88 |
Organism: | Homo sapiens (Human) |
Description: | P25101 |
Residue: | 427 |
Sequence: | METLCLRASFWLALVGCVISDNPERYSTNLSNHVDDFTTFRGTELSFLVTTHQPTNLVLP
SNGSMHNYCPQQTKITSAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIA
SLALGDLIYVVIDLPINVFKLLAGRWPFDHNDFGVFLCKLFPFLQKSSVGITVLNLCALS
VDRYRAVASWSRVQGIGIPLVTAIEIVSIWILSFILAIPEAIGFVMVPFEYRGEQHKTCM
LNATSKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQ
RREVAKTVFCLVVIFALCWFPLHLSRILKKTVYNEMDKNRCELLSFLLLMDYIGINLATM
NSCINPIALYFVSKKFKNCFQSCLCCCCYQSKSLMTSVPMNGTSIQWKNHDQNNHNTDRS
SHKDSMN
|
|
|
BDBM50068742 |
---|
n/a |
---|
Name | BDBM50068742 |
Synonyms: | 4'-Isobutyl-biphenyl-2-sulfonic acid (3,4-dimethyl-isoxazol-5-yl)-amide | CHEMBL105490 |
Type | Small organic molecule |
Emp. Form. | C21H24N2O3S |
Mol. Mass. | 384.492 |
SMILES | CC(C)Cc1ccc(cc1)-c1ccccc1S(=O)(=O)Nc1onc(C)c1C |
Structure |
|