| Reaction Details |
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 | Report a problem with these data |
| Target | Histamine H3 receptor |
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| Ligand | BDBM50091376 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_86898 (CHEMBL698408) |
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| Ki | 4.4±n/a nM |
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| Citation |  Sasse, A; Sadek, B; Ligneau, X; Elz, S; Pertz, HH; Luger, P; Ganellin, CR; Arrang, JM; Schwartz, JC; Schunack, W; Stark, H New histamine H(3)-receptor ligands of the proxifan series: imoproxifan and other selective antagonists with high oral in vivo potency. J Med Chem43:3335-43 (2000) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Histamine H3 receptor |
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| Name: | Histamine H3 receptor |
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| Synonyms: | HH3R | HRH3_RAT | Hrh3 |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 48607.98 |
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| Organism: | Rattus norvegicus (rat) |
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| Description: | n/a |
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| Residue: | 445 |
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| Sequence: | MERAPPDGLMNASGTLAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFV
ADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCAS
SVFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMALVWVLAFLLYGPAILSWEYLSGG
SSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGGREAG
PEPPPDAQPSPPPAPPSCWGCWPKGHGEAMPLHRYGVGEAGPGVEAGEAALGGGSGGGAA
ASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSITQRFRLSRDKKVAKSL
AIIVSIFGLCWAPYTLLMIIRAACHGRCIPDYWYETSFWLLWANSAVNPVLYPLCHYSFR
RAFTKLLCPQKLKVQPHGSLEQCWK
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| BDBM50091376 |
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| n/a |
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| Name | BDBM50091376 |
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| Synonyms: | CHEMBL116270 | CHEMBL80348 | Cyclopropyl-{4-[3-(1H-imidazol-4-yl)-propoxy]-phenyl}-methanone oxime; compound with but-2-enedioic acid (0.25M H2O) |
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| Type | Small organic molecule |
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| Emp. Form. | C16H19N3O2 |
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| Mol. Mass. | 285.341 |
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| SMILES | O=NC(C1CC1)c1ccc(OCCCc2cnc[nH]2)cc1 |
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| Structure | 
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