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TargetNPY2R
LigandBDBM50091668
Substrate/Competitorn/a
Meas. Tech.ChEMBL_154174
IC50 0.91±n/a nM
Citation Balasubramaniam ATao ZZhai WStein MSheriff SChance WTFischer JEEden PETaylor JELiu CDMcFadden DWVoisin TRoze CLaburthe M Structure-activity studies including a Psi(CH(2)-NH) scan of peptide YY (PYY) active site, PYY(22-36), for interaction with rat intestinal PYY receptors: development of analogues with potent in vivo activity in the intestine. J Med Chem 43:3420-7 (2000) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
NPY2R
Name:Neuropeptide Y receptor type 2
Synonyms:NPY-Y2 | Neuropeptide Y receptor type 2 | Neuropeptide Y/peptide YY-Y2 receptor
Type:Enzyme Catalytic Domain
Mol. Mass.:42514.44
Organism:RAT
Description:NPY-Y2 NPY2R RAT::Q9ERC0
Residue:381
Sequence:
MGPLGAEADENQTVEVKVELYGSGPTTPRGELPPDPEPELIDSTKLVEVQVVLILAYCSI
ILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGP
VLCHLVPYAQGLAVQVSTITLTVIALDRHRCIVYHLESKISKQISFLIIGLAWGVSALLA
SPLAIFREYSLIEIIPDFEIVACTEKWPGEEKSVYGTVYSLSTLLILYVLPLGIISFSYT
RIWSKLKNHVSPGAASDHYHQRRHKTTKMLVCVVVVFAVSWLPLHAFQLAVDIDSHVLDL
KEYKLIFTVFHIIAMCSTFANPLLYGWMNSNYRKAFLSAFRCEQRLDAIHSEVSMTFKAK
KNLEVKKNNGLTDSFSEATNV
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  Blast E-value cutoff:
BDBM50091668
n/a
NameBDBM50091668
Synonyms:AcPYY(22-36) | CHEMBL269267 | N-alpha-Ac-PYY(22-36)-NH2(N-alpha-Ac-ASLAHYLNLVTRQRY-NH2)
TypeSmall organic molecule
Emp. Form.C86H139N29O22
Mol. Mass.1931.205
SMILESCC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(C)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O
Structure
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