Ki Summary

Reaction Details

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Target

Neuropeptide Y receptor type 2

Ligand

BDBM50091659

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_154174 (CHEMBL762378)

IC50

1.12±n/a nM

Citation

Balasubramaniam, A; Tao, Z; Zhai, W; Stein, M; Sheriff, S; Chance, WT; Fischer, JE; Eden, PE; Taylor, JE; Liu, CD; McFadden, DW; Voisin, T; Roze, C; Laburthe, M Structure-activity studies including a Psi(CH(2)-NH) scan of peptide YY (PYY) active site, PYY(22-36), for interaction with rat intestinal PYY receptors: development of analogues with potent in vivo activity in the intestine. J Med Chem43:3420-7 (2000) [PubMed]

More Info.:

Get all data from this article, Assay Method

Neuropeptide Y receptor type 2

Name:

Neuropeptide Y receptor type 2

Synonyms:

NPY-Y2 | NPY2R | Neuropeptide Y receptor type 2 | Neuropeptide Y/peptide YY-Y2 receptor

Type:

Enzyme Catalytic Domain

Mol. Mass.:

42514.44

Organism:

RAT

Description:

NPY-Y2 NPY2R RAT::Q9ERC0

Residue:

381

Sequence:

MGPLGAEADENQTVEVKVELYGSGPTTPRGELPPDPEPELIDSTKLVEVQVVLILAYCSI
ILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGP
VLCHLVPYAQGLAVQVSTITLTVIALDRHRCIVYHLESKISKQISFLIIGLAWGVSALLA
SPLAIFREYSLIEIIPDFEIVACTEKWPGEEKSVYGTVYSLSTLLILYVLPLGIISFSYT
RIWSKLKNHVSPGAASDHYHQRRHKTTKMLVCVVVVFAVSWLPLHAFQLAVDIDSHVLDL
KEYKLIFTVFHIIAMCSTFANPLLYGWMNSNYRKAFLSAFRCEQRLDAIHSEVSMTFKAK
KNLEVKKNNGLTDSFSEATNV

BDBM50091659

n/a

Name

BDBM50091659

Synonyms:

CHEMBL384306 | N-alpha-Ac-[Trp27,CH2-NH-35-36]PYY(22-36)-NH2(N-alpha-Ac-ASLAHWLNLVTRQR-CH2-NH-Y-NH2)

Type

Small organic molecule

Emp. Form.

C88H142N30O20

Mol. Mass.

1940.2581

SMILES

CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(C)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)CN[C@@H](Cc1ccc(O)cc1)C(N)=O

Structure