| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Atrial natriuretic peptide receptor 1 |
|---|
| Ligand | BDBM50091756 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_34995 |
|---|
| Ki | 2900±n/a nM |
|---|
| Citation |  Veale, CA; Alford, VC; Aharony, D; Banville, DL; Bialecki, RA; Brown, FJ; Damewood, JR; Dantzman, CL; Edwards, PD; Jacobs, RT; Mauger, RC; Murphy, MM; Palmer, W; Pine, KK; Rumsey, WL; Garcia-Davenport, LE; Shaw, A; Steelman, GB; Surian, JM; Vacek, EP The discovery of non-basic atrial natriuretic peptide clearance receptor antagonists. Part 1. Bioorg Med Chem Lett10:1949-52 (2001) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Atrial natriuretic peptide receptor 1 |
|---|
| Name: | Atrial natriuretic peptide receptor 1 |
|---|
| Synonyms: | ANP-A | ANPRA | ANPRA_HUMAN | Atrial natriuretic peptide A-type receptor | Atrial natriuretic peptide receptor | Atrial natriuretic peptide receptor A | GC-A | Guanylate cyclase | NPR-A | NPR1 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 118919.35 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_700223 |
|---|
| Residue: | 1061 |
|---|
| Sequence: | MPGPRRPAGSRLRLLLLLLLPPLLLLLRGSHAGNLTVAVVLPLANTSYPWSWARVGPAVE
LALAQVKARPDLLPGWTVRTVLGSSENALGVCSDTAAPLAAVDLKWEHNPAVFLGPGCVY
AAAPVGRFTAHWRVPLLTAGAPALGFGVKDEYALTTRAGPSYAKLGDFVAALHRRLGWER
QALMLYAYRPGDEEHCFFLVEGLFMRVRDRLNITVDHLEFAEDDLSHYTRLLRTMPRKGR
VIYICSSPDAFRTLMLLALEAGLCGEDYVFFHLDIFGQSLQGGQGPAPRRPWERGDGQDV
SARQAFQAAKIITYKDPDNPEYLEFLKQLKHLAYEQFNFTMEDGLVNTIPASFHDGLLLY
IQAVTETLAHGGTVTDGENITQRMWNRSFQGVTGYLKIDSSGDRETDFSLWDMDPENGAF
RVVLNYNGTSQELVAVSGRKLNWPLGYPPPDIPKCGFDNEDPACNQDHLSTLEVLALVGS
LSLLGILIVSFFIYRKMQLEKELASELWRVRWEDVEPSSLERHLRSAGSRLTLSGRGSNY
GSLLTTEGQFQVFAKTAYYKGNLVAVKRVNRKRIELTRKVLFELKHMRDVQNEHLTRFVG
ACTDPPNICILTEYCPRGSLQDILENESITLDWMFRYSLTNDIVKGMLFLHNGAICSHGN
LKSSNCVVDGRFVLKITDYGLESFRDLDPEQGHTVYAKKLWTAPELLRMASPPVRGSQAG
DVYSFGIILQEIALRSGVFHVEGLDLSPKEIIERVTRGEQPPFRPSLALQSHLEELGLLM
QRCWAEDPQERPPFQQIRLTLRKFNRENSSNILDNLLSRMEQYANNLEELVEERTQAYLE
EKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTL
LNDLYTCFDAVIDNFDVYKVETIGDAYMVVSGLPVRNGRLHACEVARMALALLDAVRSFR
IRHRPQEQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHLSSET
KAVLEEFGGFELELRGDVEMKGKGKVRTYWLLGERGSSTRG
|
|
|
|---|
| BDBM50091756 |
|---|
| n/a |
|---|
| Name | BDBM50091756 |
|---|
| Synonyms: | (S)-3-[(2S,3S)-2-((S)-2-Acetylamino-5-guanidino-pentanoylamino)-3-methyl-pentanoylamino]-N-[(S)-4-guanidino-1-((S)-2-methyl-pentylcarbamoyl)-butyl]-succinamic acid | CHEMBL61413 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C30H57N11O7 |
|---|
| Mol. Mass. | 683.8431 |
|---|
| SMILES | CCC[C@H](C)CNC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(C)=O)[C@@H](C)CC |
|---|
| Structure | 
|
|---|
Search and Browse
