Reaction Details | |||
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Target | DNA polymerase alpha catalytic subunit | ||
Ligand | BDBM50090910 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEBML_32951 | ||
IC50 | 3000±n/a nM | ||
Citation | Vaillancourt, VA; Cudahy, MM; Staley, SA; Brideau, RJ; Conrad, SJ; Knechtel, ML; Oien, NL; Wieber, JL; Yagi, Y; Wathen, MW Naphthalene carboxamides as inhibitors of human cytomegalovirus DNA polymerase. Bioorg Med Chem Lett10:2079-81 (2000) [PubMed] | ||
More Info.: | Get all data from this article, Assay Method | ||
DNA polymerase alpha catalytic subunit | |||
Name: | DNA polymerase alpha catalytic subunit | ||
Synonyms: | DNA polymerase (alpha/delta/epsilon) | DNA polymerase alpha subunit | DPOLA_HUMAN | POLA | POLA1 | ||
Type: | PROTEIN | ||
Mol. Mass.: | 165895.25 | ||
Organism: | Homo sapiens (Human) | ||
Description: | ChEMBL_1365493 | ||
Residue: | 1462 | ||
Sequence: |
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BDBM50090910 | |||
n/a | |||
Name | BDBM50090910 | ||
Synonyms: | 3alpha,16,17,18-tetrahydroxyaphidicolone | 6,13-di(hydroxymethyl)-2,6-dimethyl-(1S,2S,5R,6R,7R)-tetracyclo[10.3.1.01,10.02,7]hexadecane-5,13-diol | 6,13-di(hydroxymethyl)-2,6-dimethyl-(1S,2S,5R,6R,7R,10S,12R,13R)-tetracyclo[10.3.1.01,10.02,7]hexadecane-5,13-diol (Aphidicolin) | 6,13-di(hydroxymethyl)-2,6-dimethyl-(1S,2S,5R,6R,7R,10S,12R,13R)-tetracyclo[10.3.1.01,10.02,7]hexadecane-5,13-diol(Aphidicolin) | CHEMBL29711 | aphidicholin | aphidicolin | cid_457964 | ||
Type | Small organic molecule | ||
Emp. Form. | C20H34O4 | ||
Mol. Mass. | 338.4816 | ||
SMILES | C[C@@]1(CO)[C@H](O)CC[C@@]2(C)[C@H]1CC[C@H]1C[C@@H]3C[C@]21CC[C@]3(O)CO |r| | ||
Structure |