| Reaction Details |
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 | Report a problem with these data |
| Target | Kappa-type opioid receptor |
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| Ligand | BDBM50092516 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_145387 (CHEMBL750077) |
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| Ki | 15±n/a nM |
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| Citation |  Siener, T; Cambareri, A; Kuhl, U; Englberger, W; Haurand, M; Kögel, B; Holzgrabe, U Synthesis and opioid receptor affinity of a series of 2, 4-diaryl-substituted 3,7-diazabicylononanones. J Med Chem43:3746-51 (2000) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Kappa-type opioid receptor |
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| Name: | Kappa-type opioid receptor |
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| Synonyms: | K-OR-1 | KOR-1 | Kappa-opioid receptor (KOR) | Kappa-type opioid receptor (KOPR) | Kappa-type opioid receptor (KOR) | Kappa-type opioid receptor (Kappa) | OPIATE Kappa | OPRK | OPRK1 | OPRK_HUMAN | kappa opioid receptor (KOR) |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 42648.76 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P41145 |
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| Residue: | 380 |
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| Sequence: | MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPV
IITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYL
MNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINI
CIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVL
IIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALG
STSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRV
RNTVQDPAYLRDIDGMNKPV
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|
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| BDBM50092516 |
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| n/a |
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| Name | BDBM50092516 |
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| Synonyms: | 3-{[(Methoxycarbonyl-pyridin-2-yl-methyl)-methyl-amino]-pyridin-2-yl-methyl}-1-methyl-4-oxo-piperidine-3-carboxylic acid methyl ester | CHEMBL177284 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H26N4O5 |
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| Mol. Mass. | 438.4763 |
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| SMILES | COC(=O)C12CN(C)CC(C(N(C)C1c1ccccn1)c1ccccn1)(C(=O)OC)C2=O |TLB:12:11:30:6.5.8,20:10:30:6.5.8,14:13:30:6.5.8| |
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| Structure | 
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