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Target5-hydroxytryptamine receptor 4
LigandBDBM50092556
Substrate/Competitorn/a
Meas. Tech.ChEMBL_3573 (CHEMBL620706)
Ki 23.1±n/a nM
Citation Curtet, SSoulier, JLZahradnik, IGiner, MBerque-Bestel, IMialet, JLezoualc'h, FDonzeau-Gouge, PSicsic, SFischmeister, RLanglois, M New arylpiperazine derivatives as antagonists of the human cloned 5-HT(4) receptor isoforms. J Med Chem43:3761-9 (2000) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
5-hydroxytryptamine receptor 4
Name:5-hydroxytryptamine receptor 4
Synonyms:5-HT-4 | 5-HT4 | 5-HT4S | 5-HT4a | 5-HT4b | 5-HT4c | 5-HT4d | 5-HT4hb | 5-hydroxytryptamine receptor 4 | 5-hydroxytryptamine receptor 4 (5-HT4) | 5HT4R_HUMAN | HTR4 | Serotonin (5-HT) receptor | Serotonin (5-HT3) receptor | Serotonin 4 (5-HT4) receptor | Serotonin Receptor 4
Type:Enzyme
Mol. Mass.:43767.54
Organism:Homo sapiens (Human)
Description:Q13639
Residue:388
Sequence:
MDKLDANVSSEEGFGSVEKVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIV
SLAFADLLVSVLVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYY
AICCQPLVYRNKMTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSN
STYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSESRP
QSADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQVWTAFLWL
GYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRPSILGQTVPCSTTTINGSTHVLRD
AVECGGQWESQCHPPATSPLVAAQPSDT
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50092556
n/a
NameBDBM50092556
Synonyms:4-Amino-5-chloro-2-methoxy-benzoic acid 2-[4-(4-fluoro-phenyl)-piperazin-1-yl]-ethyl ester | CHEMBL333028
TypeSmall organic molecule
Emp. Form.C20H23ClFN3O3
Mol. Mass.407.866
SMILESCOc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(CC1)c1ccc(F)cc1
Structure
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