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TargetDelta-type opioid receptor
LigandBDBM50092669
Substrate/Competitorn/a
Meas. Tech.ChEMBL_145306 (CHEMBL752841)
EC50 3.6±n/a nM
Citation Plobeck, NDelorme, DWei, ZYYang, HZhou, FSchwarz, PGawell, LGagnon, HPelcman, BSchmidt, RYue, SYWalpole, CBrown, WZhou, ELabarre, MPayza, KSt-Onge, SKamassah, AMorin, PEProjean, DDucharme, JRoberts, E New diarylmethylpiperazines as potent and selective nonpeptidic delta opioid receptor agonists with increased In vitro metabolic stability. J Med Chem43:3878-94 (2000) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Delta-type opioid receptor
Name:Delta-type opioid receptor
Synonyms:D-OR-1 | DOR-1 | Delta opioid receptor | Delta-type opioid receptor (Delta) | OPIATE Delta | OPRD | OPRD1 | OPRD_HUMAN | OPRK1 | opioid receptor, delta 1
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:40382.98
Organism:Homo sapiens (Human)
Description:Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the delta opioid receptor.
Residue:372
Sequence:
MEPAPSAGAELQPPLFANASDAYPSACPSAGANASGPPGARSASSLALAIAITALYSAVC
AVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELL
CKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVG
VPIMVMAVTRPRDGAVVCMLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRL
RSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRDPLVVAAL
HLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCGRPDPSSFSRAREATARERVTAC
TPSDGPGGGAAA
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  Blast E-value cutoff:
BDBM50092669
n/a
NameBDBM50092669
Synonyms:CHEMBL129420 | N,N-Diethyl-4-(piperazin-1-yl-quinolin-8-yl-methyl)-benzamide
TypeSmall organic molecule
Emp. Form.C25H30N4O
Mol. Mass.402.5319
SMILESCCN(CC)C(=O)c1ccc(cc1)C(N1CCNCC1)c1cccc2cccnc12
Structure
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