Ki Summary

Reaction Details

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Target

Delta-type opioid receptor

Ligand

BDBM50092702

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_145330 (CHEMBL750418)

IC50

2.1±n/a nM

Citation

Wei, ZY; Brown, W; Takasaki, B; Plobeck, N; Delorme, D; Zhou, F; Yang, H; Jones, P; Gawell, L; Gagnon, H; Schmidt, R; Yue, SY; Walpole, C; Payza, K; St-Onge, S; Labarre, M; Godbout, C; Jakob, A; Butterworth, J; Kamassah, A; Morin, PE; Projean, D; Ducharme, J; Roberts, E N,N-Diethyl-4-(phenylpiperidin-4-ylidenemethyl)benzamide: a novel, exceptionally selective, potent delta opioid receptor agonist with oral bioavailability and its analogues. J Med Chem43:3895-905 (2000) [PubMed]

More Info.:

Get all data from this article, Assay Method

Delta-type opioid receptor

Name:

Delta-type opioid receptor

Synonyms:

Type:

G Protein-Coupled Receptor (GPCR)

Mol. Mass.:

40382.98

Organism:

Homo sapiens (Human)

Description:

Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the delta opioid receptor.

Residue:

372

Sequence:

MEPAPSAGAELQPPLFANASDAYPSACPSAGANASGPPGARSASSLALAIAITALYSAVC
AVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELL
CKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVG
VPIMVMAVTRPRDGAVVCMLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRL
RSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRDPLVVAAL
HLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCGRPDPSSFSRAREATARERVTAC
TPSDGPGGGAAA

BDBM50092702

n/a

Name

BDBM50092702

Synonyms:

CHEMBL129693 | N,N-Diethyl-4-[(4-methylsulfanyl-phenyl)-piperidin-4-ylidene-methyl]-benzamide

Type

Small organic molecule

Emp. Form.

C24H30N2OS

Mol. Mass.

394.573

SMILES

[#6]-[#6]-[#7](-[#6]-[#6])-[#6](=O)-c1ccc(cc1)-[#6](=[#6]-1/[#6]-[#6]-[#7]-[#6]-[#6]-1)\c1ccc(-[#16]-[#6])cc1

Structure