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TargetLactoylglutathione lyase
LigandBDBM50092826
Substrate/Competitorn/a
Meas. Tech.ChEMBL_71286 (CHEMBL684427)
Ki 1200±n/a nM
Citation Kalsi, AKavarana, MJLu, TWhalen, DLHamilton, DSCreighton, DJ Role of hydrophobic interactions in binding S-(N-aryl/alkyl-N-hydroxycarbamoyl)glutathiones to the active site of the antitumor target enzyme glyoxalase I. J Med Chem43:3981-6 (2000) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Lactoylglutathione lyase
Name:Lactoylglutathione lyase
Synonyms:Aldoketomutase | GLO1 | Glx I | Glyoxalase 1 (GLO1) | Glyoxalase I | Ketone-aldehyde mutase | LGUL_HUMAN | Methylglyoxalase | S-D-lactoylglutathione methylglyoxal lyase
Type:Enzyme
Mol. Mass.:20772.95
Organism:Homo sapiens (Human)
Description:Q04760
Residue:184
Sequence:
MAEPQPPSGGLTDEAALSCCSDADPSTKDFLLQQTMLRVKDPKKSLDFYTRVLGMTLIQK
CDFPIMKFSLYFLAYEDKNDIPKEKDEKIAWALSRKATLELTHNWGTEDDETQSYHNGNS
DPRGFGHIGIAVPDVYSACKRFEELGVKFVKKPDDGKMKGLAFIQDPDGYWIEILNPNKM
ATLM
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  Blast E-value cutoff:
BDBM50092826
n/a
NameBDBM50092826
Synonyms:(2S)-2-amino-5-{[(1R)-1-[({[(4-bromophenyl)(hydroxy)amino]carbonyl}thio)methyl]-2-(carboxyamino)-2-oxoethyl]amino}-5-oxopentanoic acid | (S)-2-amino-5-((R)-3-((4-bromophenyl)hydroxycarbamoylthio)-1-(carboxymethylamino)-1-oxopropan-2-ylamino)-5-oxopentanoic acid | CHEMBL128872 | S-(N-4bromophenyl-N-hydroxycarbamoyl)glutathione
TypeSmall organic molecule
Emp. Form.C17H21BrN4O8S
Mol. Mass.521.34
SMILESN[C@@H](CCC(=O)N[C@@H](CSC(=O)N(O)c1ccc(Br)cc1)C(=O)NCC(O)=O)C(O)=O
Structure
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