| Reaction Details |
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 | Report a problem with these data |
| Target | Beta-2 adrenergic receptor |
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| Ligand | BDBM50019355 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_38313 (CHEMBL647876) |
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| IC50 | 6.1±n/a nM |
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| Citation |  Parmee, ER; Brockunier, LL; He, J; Singh, SB; Candelore, MR; Cascieri, MA; Deng, L; Liu, Y; Tota, L; Wyvratt, MJ; Fisher, MH; Weber, AE Tetrahydroisoquinoline derivatives containing a benzenesulfonamide moiety as potent, selective human beta3 adrenergic receptor agonists. Bioorg Med Chem Lett10:2283-6 (2001) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Beta-2 adrenergic receptor |
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| Name: | Beta-2 adrenergic receptor |
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| Synonyms: | ADRB2 | ADRB2R | ADRB2_HUMAN | B2AR | Beta-2 adrenoceptor | Beta-2 adrenoreceptor |
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| Type: | n/a |
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| Mol. Mass.: | 46461.69 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P07550 |
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| Residue: | 413 |
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| Sequence: | MGQPGNGSAFLLAPNGSHAPDHDVTQERDEVWVVGMGIVMSLIVLAIVFGNVLVITAIAK
FERLQTVTNYFITSLACADLVMGLAVVPFGAAHILMKMWTFGNFWCEFWTSIDVLCVTAS
IETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRATHQE
AINCYANETCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLQKIDKSEGRF
HVQNLSQVEQDGRTGHGLRRSSKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQD
NLIRKEVYILLNWIGYVNSGFNPLIYCRSPDFRIAFQELLCLRRSSLKAYGNGYSSNGNT
GEQSGYHVEQEKENKLLCEDLPGTEDFVGHQGTVPSDNIDSQGRNCSTNDSLL
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| BDBM50019355 |
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| n/a |
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| Name | BDBM50019355 |
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| Synonyms: | 1-(3,4,5-Trimethoxy-benzyl)-1,2,3,4-tetrahydro-isoquinoline-6,7-diol | 1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline-6,7-diol | CHEMBL299175 | R(+)-TMQ | TMQ, Racemic | Tretoquinol |
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| Type | Small organic molecule |
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| Emp. Form. | C19H23NO5 |
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| Mol. Mass. | 345.3896 |
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| SMILES | COc1cc(CC2NCCc3cc(O)c(O)cc23)cc(OC)c1OC |
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| Structure | 
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