| Reaction Details |
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 | Report a problem with these data |
| Target | Growth factor receptor-bound protein 2 |
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| Ligand | BDBM50093127 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_63777 |
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| IC50 | 1200±n/a nM |
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| Citation |  Furet, P; Caravatti, G; Denholm, AA; Faessler, A; Fretz, H; García-Echeverría, C; Gay, B; Irving, E; Press, NJ; Rahuel, J; Schoepfer, J; Walker, CV Structure-based design and synthesis of phosphinate isosteres of phosphotyrosine for incorporation in Grb2-SH2 domain inhibitors. Part 1. Bioorg Med Chem Lett10:2337-41 (2001) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Growth factor receptor-bound protein 2 |
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| Name: | Growth factor receptor-bound protein 2 |
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| Synonyms: | ASH | GRB2 | GRB2 adapter protein | GRB2_HUMAN | Grb2-SH2 | Growth factor receptor-bound protein 2 |
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| Type: | Protein |
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| Mol. Mass.: | 25205.04 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P62993 |
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| Residue: | 217 |
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| Sequence: | MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPW
FFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFL
WVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQPTYVQALFDFDPQEDGELGFRRG
DFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVNRNV
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| BDBM50093127 |
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| n/a |
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| Name | BDBM50093127 |
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| Synonyms: | (4-{(S)-2-Acetylamino-2-[1-((1R,2S)-2-carbamoyl-cyclohexylcarbamoyl)-cyclohexylcarbamoyl]-ethyl}-benzyl)-benzyl-phosphinic acid | CHEMBL78061 |
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| Type | Small organic molecule |
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| Emp. Form. | C33H45N4O6P |
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| Mol. Mass. | 624.7074 |
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| SMILES | CC(=O)N[C@@H](Cc1ccc(CP(O)(=O)Cc2ccccc2)cc1)C(=O)NC1(CCCCC1)C(=O)N[C@@H]1CCCC[C@@H]1C(N)=O |
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| Structure | 
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