Reaction Details |
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Target | Coagulation factor X |
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Ligand | BDBM50093304 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_48967 (CHEMBL661678) |
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IC50 | 16000±n/a nM |
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Citation | Dudley, DA; Bunker, AM; Chi, L; Cody, WL; Holland, DR; Ignasiak, DP; Janiczek-Dolphin, N; McClanahan, TB; Mertz, TE; Narasimhan, LS; Rapundalo, ST; Trautschold, JA; Van Huis, CA; Edmunds, JJ Rational design, synthesis, and biological activity of benzoxazinones as novel factor Xa inhibitors. J Med Chem43:4063-70 (2000) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Coagulation factor X |
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Name: | Coagulation factor X |
Synonyms: | Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | FA10_HUMAN | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor |
Type: | Enzyme |
Mol. Mass.: | 54726.60 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 488 |
Sequence: | MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEE
TCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKN
CELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERR
KRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQE
CKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGE
AVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGI
VSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSG
GPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPE
VITSSPLK
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BDBM50093304 |
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n/a |
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Name | BDBM50093304 |
Synonyms: | 2-(2-Chloro-phenyl)-4-[5-(2,6-dimethyl-piperidin-1-yl)-pentyl]-4H-benzo[1,4]oxazin-3-one | CHEMBL423149 |
Type | Small organic molecule |
Emp. Form. | C26H33ClN2O2 |
Mol. Mass. | 441.005 |
SMILES | CC1CCCC(C)N1CCCCCN1C(=O)C(Oc2ccccc12)c1ccccc1Cl |
Structure |
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