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TargetMethylated-DNA--protein-cysteine methyltransferase
LigandBDBM5484
Substrate/Competitorn/a
Meas. Tech.ChEMBL_28283 (CHEMBL645824)
IC50 200±n/a nM
Citation Griffin, RJArris, CEBleasdale, CBoyle, FTCalvert, AHCurtin, NJDalby, CKanugula, SLembicz, NKNewell, DRPegg, AEGolding, BT Resistance-modifying agents. 8. Inhibition of O(6)-alkylguanine-DNA alkyltransferase by O(6)-alkenyl-, O(6)-cycloalkenyl-, and O(6)-(2-oxoalkyl)guanines and potentiation of temozolomide cytotoxicity in vitro by O(6)-(1-cyclopentenylmethyl)guanine. J Med Chem43:4071-83 (2000) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Methylated-DNA--protein-cysteine methyltransferase
Name:Methylated-DNA--protein-cysteine methyltransferase
Synonyms:6-O-methylguanine-DNA methyltransferase | MGMT | MGMT_HUMAN
Type:PROTEIN
Mol. Mass.:21651.27
Organism:Homo sapiens (Human)
Description:ChEMBL_144711
Residue:207
Sequence:
MDKDCEMKRTTLDSPLGKLELSGCEQGLHEIKLLGKGTSAADAVEVPAPAAVLGGPEPLM
QCTAWLNAYFHQPEAIEEFPVPALHHPVFQQESFTRQVLWKLLKVVKFGEVISYQQLAAL
AGNPKAARAVGGAMRGNPVPILIPCHRVVCSSGAVGNYSGGLAVKEWLLAHEGHRLGKPG
LGGSSGLAGAWLKGAGATSGSPPAGRN
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  Blast E-value cutoff:
BDBM5484
n/a
NameBDBM5484
Synonyms:6-(cyclopent-1-en-1-ylmethoxy)-9H-purin-2-amine | CHEMBL405259 | O6-Substituted Guanine Deriv. 24
TypeSmall organic molecule
Emp. Form.C11H13N5O
Mol. Mass.231.2538
SMILESNc1nc(OCC2=CCCC2)c2[nH]cnc2n1 |t:6|
Structure
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