Reaction Details |
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Target | Endothelin-1 receptor |
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Ligand | BDBM50094002 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_63349 |
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IC50 | 6.2±n/a nM |
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Citation | Zhang, J; Didierlaurent, S; Fortin, M; Lefrançois, D; Uridat, E; Vevert, JP Potent nonpeptide endothelin antagonists: synthesis and structure-activity relationships of pyrazole-5-carboxylic acids. Bioorg Med Chem Lett10:2575-8 (2001) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Endothelin-1 receptor |
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Name: | Endothelin-1 receptor |
Synonyms: | EDNRA_RAT | ENDOTHELIN A | Ednra | Endothelin receptor | Endothelin-1 receptor |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 48256.91 |
Organism: | RAT |
Description: | ENDOTHELIN A EDNRA RAT::P26684 |
Residue: | 426 |
Sequence: | MGVLCFLASFWLALVGGAIADNAERYSANLSSHVEDFTPFPGTEFNFLGTTLQPPNLALP
SNGSMHGYCPQQTKITTAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIA
SLALGDLIYVVIDLPINVFKLLAGRWPFDHNDFGVFLCKLFPFLQKSSVGITVLNLCALS
VDRYRAVASWSRVQGIGIPLITAIEIVSIWILSFILAIPEAIGFVMVPFEYKGEQHRTCM
LNATTKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQ
RREVAKTVFCLVVIFALCWFPLHLSRILKKTVYDEMDKNRCELLSFLLLMDYIGINLATM
NSCINPIALYFVSKKFKNCFQSCLCCCCHQSKSLMTSVPMNGTSIQWKNQEQNHNTERSS
HKDSMN
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BDBM50094002 |
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n/a |
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Name | BDBM50094002 |
Synonyms: | 2-(3-Carboxy-benzyl)-4-(6-chloro-benzo[1,3]dioxol-5-ylmethyl)-5-thiophen-2-yl-2H-pyrazole-3-carboxylic acid | CHEMBL315638 |
Type | Small organic molecule |
Emp. Form. | C24H17ClN2O6S |
Mol. Mass. | 496.92 |
SMILES | OC(=O)c1c(Cc2cc3OCOc3cc2Cl)c(nn1Cc1cccc(c1)C(O)=O)-c1cccs1 |
Structure |
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