| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Coagulation factor X |
|---|
| Ligand | BDBM50094114 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_48664 (CHEMBL657716) |
|---|
| Ki | 2.4±n/a nM |
|---|
| Citation |  Han, Q; Dominguez, C; Stouten, PF; Park, JM; Duffy, DE; Galemmo, RA; Rossi, KA; Alexander, RS; Smallwood, AM; Wong, PC; Wright, MM; Luettgen, JM; Knabb, RM; Wexler, RR Design, synthesis, and biological evaluation of potent and selective amidino bicyclic factor Xa inhibitors. J Med Chem43:4398-415 (2000) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Coagulation factor X |
|---|
| Name: | Coagulation factor X |
|---|
| Synonyms: | Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | FA10_HUMAN | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 54726.60 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | n/a |
|---|
| Residue: | 488 |
|---|
| Sequence: | MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEE
TCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKN
CELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERR
KRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQE
CKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGE
AVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGI
VSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSG
GPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPE
VITSSPLK
|
|
|
|---|
| BDBM50094114 |
|---|
| n/a |
|---|
| Name | BDBM50094114 |
|---|
| Synonyms: | 2-(6-Carbamimidoyl-benzoimidazol-1-yl)-N-(2'-sulfamoyl-biphenyl-4-yl)-acetamide | CHEMBL343495 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C22H20N6O3S |
|---|
| Mol. Mass. | 448.498 |
|---|
| SMILES | NC(=N)c1ccc2ncn(CC(=O)Nc3ccc(cc3)-c3ccccc3S(N)(=O)=O)c2c1 |
|---|
| Structure | 
|
|---|
Search and Browse
