Reaction Details |
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Target | Adenosine kinase |
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Ligand | BDBM50094703 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_31129 (CHEMBL643557) |
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IC50 | 50±n/a nM |
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Citation | Cowart, M; Lee, CH; Gfesser, GA; Bayburt, EK; Bhagwat, SS; Stewart, AO; Yu, H; Kohlhaas, KL; McGaraughty, S; Wismer, CT; Mikusa, J; Zhu, C; Alexander, KM; Jarvis, MF; Kowaluk, EA Structure-activity studies of 5-substituted pyridopyrimidines as adenosine kinase inhibitors. Bioorg Med Chem Lett11:83-6 (2001) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Adenosine kinase |
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Name: | Adenosine kinase |
Synonyms: | ADENOSINE | ADK_RAT | Adenosine 5-phosphotransferase | Adenosine Kinase (AK) | Adenosine kinase | Adk |
Type: | Enzyme |
Mol. Mass.: | 40130.14 |
Organism: | Rattus norvegicus (rat) |
Description: | Rat brain cytosol as enzyme source. |
Residue: | 361 |
Sequence: | MAAADEPKPKKLKVEAPEALSENVLFGMGNPLLDISAVVDKDFLDKYSLKPNDQILAEDK
HKELFDELVKKFKVEYHAGGSTQNSMKVAQWMIQEPHRAATFFGCIGIDKFGEILKSKAA
DAHVDAHYYEQNEQPTGTCAACITGGNRSLVANLAAANCYKKEKHLDLENNWMLVEKARV
YYIAGFFLTVSPESVLKVARYAAENNRTFTLNLSAPFISQFFKEALMEVMPYVDILFGNE
TEAATFAREQGFETKDIKEIARKTQALPKVNSKRQRTVIFTQGRDDTIVATGNDVTAFPV
LDQNQEEIVDTNGAGDAFVGGFLSQLVSNKPLTECIRAGHYAASVIIRRTGCTFPEKPDF
H
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BDBM50094703 |
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n/a |
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Name | BDBM50094703 |
Synonyms: | 5-(3-Bromo-phenyl)-7-(6-morpholin-4-yl-pyridin-3-yl)-pyrido[2,3-d]pyrimidin-4-ylamine | 5-(3-bromophenyl)-7-(6-morpholin-4-ylpyridin-3-yl)pyrido[2,3-d]pyrimidin-4-ylamine | ABT-702 | CHEMBL66089 |
Type | Small organic molecule |
Emp. Form. | C22H19BrN6O |
Mol. Mass. | 463.33 |
SMILES | Nc1ncnc2nc(cc(-c3cccc(Br)c3)c12)-c1ccc(nc1)N1CCOCC1 |
Structure |
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