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TargetIntegrase
LigandBDBM23400
Substrate/Competitorn/a
Meas. Tech.ChEMBL_90549 (CHEMBL701899)
IC50<100±n/a nM
Citation Wai, JSEgbertson, MSPayne, LSFisher, TEEmbrey, MWTran, LOMelamed, JYLangford, HMGuare, JPZhuang, LGrey, VEVacca, JPHolloway, MKNaylor-Olsen, AMHazuda, DJFelock, PJWolfe, ALStillmock, KASchleif, WAGabryelski, LJYoung, SD 4-Aryl-2,4-dioxobutanoic acid inhibitors of HIV-1 integrase and viral replication in cells. J Med Chem43:4923-6 (2001) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Integrase
Name:Integrase
Synonyms:Human immunodeficiency virus type 1 integrase
Type:PROTEIN
Mol. Mass.:32231.48
Organism:Human immunodeficiency virus 1
Description:ChEMBL_90865
Residue:288
Sequence:
FLDGIDKAQDEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGI
WQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTIHTDNGSN
FTSTTVKAACWWAGIKQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAV
FIHNFKRKGGIGGYSAGERIVDIIATDIQTKELQKQITKIQNFRVYYRDSRDPLWKGPAK
LLWKGEGAVVIQDNSDIKVVPRRKVKIIRDYGKQMAGDDCVASRQDED
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM23400
n/a
NameBDBM23400
Synonyms:(2Z)-4-(3-benzylphenyl)-2-hydroxy-4-oxobut-2-enoic acid | CHEMBL193759 | CHEMBL19464 | GS-016405
TypeSmall organic molecule
Emp. Form.C17H14O4
Mol. Mass.282.2907
SMILESOC(=O)C(=O)CC(=O)c1cccc(Cc2ccccc2)c1
Structure
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