Ki Summary

Reaction Details

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Target

Muscarinic acetylcholine receptor M1

Ligand

BDBM50095656

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_138399 (CHEMBL744762)

0.88±n/a nM

Citation

Mitsuya, M; Kobayashi, K; Kawakami, K; Satoh, A; Ogino, Y; Kakikawa, T; Ohtake, N; Kimura, T; Hirose, H; Sato, A; Numazawa, T; Hasegawa, T; Noguchi, K; Mase, T A potent, long-acting, orally active (2R)-2-[(1R)-3, 3-difluorocyclopentyl]-2-hydroxy-2-phenylacetamide: novel muscarinic M(3) receptor antagonist with high selectivity for M(3) over M(2) receptors. J Med Chem43:5017-29 (2001) [PubMed]

More Info.:

Get all data from this article, Assay Method

Muscarinic acetylcholine receptor M1

Name:

Muscarinic acetylcholine receptor M1

Synonyms:

ACM1_HUMAN | CHRM1 | Cholinergic receptor, muscarinic 1 | Cholinergic, muscarinic M1

Type:

Protein

Mol. Mass.:

51442.54

Organism:

Homo sapiens (Human)

Description:

P11229

Residue:

460

Sequence:

MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVN
NYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLIS
FDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYI
QFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSS
SERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEV
VIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKE
KKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYAL
CNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC

BDBM50095656

n/a

Name

BDBM50095656

Synonyms:

2-(3,3-Difluoro-cyclopentyl)-2-hydroxy-N-[1-(3-methyl-benzyl)-piperidin-4-yl]-2-phenyl-acetamide | CHEMBL146567

Type

Small organic molecule

Emp. Form.

C26H32F2N2O2

Mol. Mass.

442.5413

SMILES

Cc1cccc(CN2CCC(CC2)NC(=O)[C@@](O)([C@@H]2CCC(F)(F)C2)c2ccccc2)c1

Structure