| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Kappa-type opioid receptor |
|---|
| Ligand | BDBM50095705 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_145566 (CHEMBL749570) |
|---|
| Ki | 3.9±n/a nM |
|---|
| Citation |  May, EL; Jacobson, AE; Mattson, MV; Traynor, JR; Woods, JH; Harris, LS; Bowman, ER; Aceto, MD Synthesis and in vitro and in vivo activity of (-)-(1R,5R,9R)- and (+)-(1S,5S,9S)-N-alkenyl-, -N-alkynyl-, and -N-cyanoalkyl-5, 9-dimethyl-2'-hydroxy-6,7-benzomorphan homologues. J Med Chem43:5030-6 (2001) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Kappa-type opioid receptor |
|---|
| Name: | Kappa-type opioid receptor |
|---|
| Synonyms: | KOR-1 | MSL-1 | OPIATE Kappa | OPRK_MOUSE | Oprk1 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 42656.78 |
|---|
| Organism: | Mus musculus (Mouse) |
|---|
| Description: | P33534 |
|---|
| Residue: | 380 |
|---|
| Sequence: | MESPIQIFRGDPGPTCSPSACLLPNSSSWFPNWAESDSNGSVGSEDQQLESAHISPAIPV
IITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSAVYL
MNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINI
CIWLLASSVGISAIVLGGTKVREDVDVIECSLQFPDDEYSWWDLFMKICVFVFAFVIPVL
IIIVCYTLMILRLKSVRLLSGSREKDRNLRRITKLVLVVVAVFIICWTPIHIFILVEALG
STSHSTAALSSYYFCIALGYTNSSLNPVLYAFLDENFKRCFRDFCFPIKMRMERQSTNRV
RNTVQDPASMRDVGGMNKPV
|
|
|
|---|
| BDBM50095705 |
|---|
| n/a |
|---|
| Name | BDBM50095705 |
|---|
| Synonyms: | 3-But-2-ynyl-6,11-dimethyl-1,2,3,4,5,6-hexahydro-2,6-methano-benzo[d]azocin-8-ol | CHEMBL147945 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C18H23NO |
|---|
| Mol. Mass. | 269.3813 |
|---|
| SMILES | CC#CCN1CC[C@@]2(C)[C@@H](C)C1Cc1ccc(O)cc21 |TLB:3:4:9:19.13.12,THB:18:19:9:4.6.5| |
|---|
| Structure | 
|
|---|
Search and Browse
