| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Reverse transcriptase/RNaseH |
|---|
| Ligand | BDBM50008310 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_197277 (CHEMBL804264) |
|---|
| EC50 | 13±n/a nM |
|---|
| Citation |  Rizzo, RC; Tirado-Rives, J; Jorgensen, WL Estimation of binding affinities for HEPT and nevirapine analogues with HIV-1 reverse transcriptase via Monte Carlo simulations. J Med Chem44:145-54 (2001) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Reverse transcriptase/RNaseH |
|---|
| Name: | Reverse transcriptase/RNaseH |
|---|
| Synonyms: | HIV-1 Reverse Transcriptase RNase H | Human immunodeficiency virus type 1 reverse transcriptase | Reverse transcriptase/RNaseH |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 65229.15 |
|---|
| Organism: | Human immunodeficiency virus 1 |
|---|
| Description: | ChEMBL_1473730 |
|---|
| Residue: | 566 |
|---|
| Sequence: | PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKRKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIRVRQLCKLLRGTKALTEVIPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLRTGKYARMRGA
HTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTP
PLVKLWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTNRGRQKVVTLTDTTNQKTELQ
AIYLALQDSGLEVNIVTDSQYALGIIQAQPDQSESELVNQIIEQLIKKEKVYLAWVPAHK
GIGGNEQVDKLVSAGIRKVLFLDGID
|
|
|
|---|
| BDBM50008310 |
|---|
| n/a |
|---|
| Name | BDBM50008310 |
|---|
| Synonyms: | 6-(3,5-Dimethyl-phenylsulfanyl)-5-ethyl-1-(2-hydroxy-ethoxymethyl)-1H-pyrimidine-2,4-dione | CHEMBL16684 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C17H22N2O4S |
|---|
| Mol. Mass. | 350.433 |
|---|
| SMILES | CCc1c(Sc2cc(C)cc(C)c2)n(COCCO)c(=O)[nH]c1=O |
|---|
| Structure | 
|
|---|
Search and Browse
