Reaction Details |
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Target | Cathepsin K |
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Ligand | BDBM50096373 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_48320 |
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Ki | 19±n/a nM |
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Citation | Fenwick, AE; Garnier, B; Gribble, AD; Ife, RJ; Rawlings, AD; Witherington, J Solid-phase synthesis of cyclic alkoxyketones, inhibitors of the cysteine protease cathepsin K. Bioorg Med Chem Lett11:195-8 (2001) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Cathepsin K |
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Name: | Cathepsin K |
Synonyms: | CATK_HUMAN | CTSK | CTSO | CTSO2 | Cathepsin O | Cathepsin O2 | Cathepsin X |
Type: | Enzyme |
Mol. Mass.: | 36975.68 |
Organism: | Homo sapiens (Human) |
Description: | P43235 |
Residue: | 329 |
Sequence: | MWGLKVLLLPVVSFALYPEEILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYISIH
NLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPLSHSRSNDTLYIPEWEGRAPDSVD
YRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGG
YMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAVA
RVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGE
NWGNKGYILMARNKNNACGIANLASFPKM
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BDBM50096373 |
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n/a |
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Name | BDBM50096373 |
Synonyms: | Biphenyl-4-carboxylic acid [(S)-3-methyl-1-(4-oxo-tetrahydro-furan-3-ylcarbamoyl)-butyl]-amide | CHEMBL58814 |
Type | Small organic molecule |
Emp. Form. | C23H26N2O4 |
Mol. Mass. | 394.4635 |
SMILES | CC(C)C[C@H](NC(=O)c1ccc(cc1)-c1ccccc1)C(=O)NC1COCC1=O |
Structure |
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