| Reaction Details |
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 | Report a problem with these data |
| Target | Proline--tRNA ligase, cytoplasmic |
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| Ligand | BDBM50097096 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_223470 |
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| IC50 | 5±n/a nM |
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| Citation |  Yu, XY; Hill, JM; Yu, G; Yang, Y; Kluge, AF; Keith, D; Finn, J; Gallant, P; Silverman, J; Lim, A A series of quinoline analogues as potent inhibitors of C. albicans prolyl tRNA synthetase. Bioorg Med Chem Lett11:541-4 (2001) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Proline--tRNA ligase, cytoplasmic |
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| Name: | Proline--tRNA ligase, cytoplasmic |
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| Synonyms: | PRS | ProRS | Proline--tRNA ligase | Prolyl-tRNA synthetase | Prolyl-tRNA synthetase, cytoplasmic | SYPC_CANAX |
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| Type: | PROTEIN |
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| Mol. Mass.: | 66202.25 |
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| Organism: | Candida albicans |
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| Description: | ChEMBL_223470 |
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| Residue: | 575 |
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| Sequence: | MIIIKRFLHIKTVPKSYGNQLSKFKYSKQIPTHEVLTKLGYITYPRAGLVNWSKMGLLIQ
NKISQIIRQRMDEIQFEEVSLSLISHKELWKLTNRWDQEEIFKLVGDEYLLVPTAEEEIT
NYVKKQFLESYKNFPLALYQINPKFRNEKRPRGGLLRGKEFLMKDAYSFDLNESEAMKTY
EKVVGAYHKIFQDLGIPYVKAEADSGDIGGSLSHEWHYLNSSGEDTVFECNECHNVSNME
KALSYPKEIDETIEVSVIYFTTEDKSTLICAYYPSNRVLEPKFIQNEIPDIDLDSINDLS
EFNHDISTRIVRIMDSRLSSRSKFPDFPISNFINRSLITTLTDIPIVLAQEGEICGHCEE
GKLSASSAIEVGHTFYLGDKYSKPLDLEVDVPTSNNSIEKQRIMMGCYGIGISRIIAAIA
EINRDEKGLKWPRSIAPWEVTVVEVSKQKQLKNVNDNNHHNNPQDNFQEIYNILNQANID
YRLDNRSDSMGKKLKQSDLLGIPLSIILGNQYPIIEIEVRGNKKNNNNNSWLQSYTENKD
QFDWKVETDAQGNDTKHYIHKDGLVTVVNSLLNDM
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| BDBM50097096 |
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| n/a |
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| Name | BDBM50097096 |
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| Synonyms: | 2-(4-Bromo-phenyl)-6-chloro-8-methyl-quinoline-4-carboxylic acid | CHEMBL357355 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H11BrClNO2 |
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| Mol. Mass. | 376.632 |
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| SMILES | Cc1cc(Cl)cc2c(cc(nc12)-c1ccc(Br)cc1)C(O)=O |
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| Structure | 
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