Ki Summary

Reaction Details

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Target

Tyrosine--tRNA ligase, cytoplasmic

Ligand

BDBM50091497

Substrate/Competitor

n/a

Meas. Tech.

ChEBML_226002

IC50

1.2±n/a nM

Citation

Brown, P; Eggleston, DS; Haltiwanger, RC; Jarvest, RL; Mensah, L; O'Hanlon, PJ; Pope, AJ Synthetic analogues of SB-219383. Novel C-glycosyl peptides as inhibitors of tyrosyl tRNA synthetase. Bioorg Med Chem Lett11:711-4 (2001) [PubMed]

More Info.:

Get all data from this article, Assay Method

Tyrosine--tRNA ligase, cytoplasmic

Name:

Tyrosine--tRNA ligase, cytoplasmic

Synonyms:

SYYC_HUMAN | Tyrosyl-tRNA synthetase | YARS | YARS1

Type:

PROTEIN

Mol. Mass.:

59145.78

Organism:

Homo sapiens (Human)

Description:

ChEMBL_211030

Residue:

528

Sequence:

MGDAPSPEEKLHLITRNLQEVLGEEKLKEILKERELKIYWGTATTGKPHVAYFVPMSKIA
DFLKAGCEVTILFADLHAYLDNMKAPWELLELRVSYYENVIKAMLESIGVPLEKLKFIKG
TDYQLSKEYTLDVYRLSSVVTQHDSKKAGAEVVKQVEHPLLSGLLYPGLQALDEEYLKVD
AQFGGIDQRKIFTFAEKYLPALGYSKRVHLMNPMVPGLTGSKMSSSEEESKIDLLDRKED
VKKKLKKAFCEPGNVENNGVLSFIKHVLFPLKSEFVILRDEKWGGNKTYTAYVDLEKDFA
AEVVHPGDLKNSVEVALNKLLDPIREKFNTPALKKLASAAYPDPSKQKPMAKGPAKNSEP
EEVIPSRLDIRVGKIITVEKHPDADSLYVEKIDVGEAEPRTVVSGLVQFVPKEELQDRLV
VVLCNLKPQKMRGVESQGMLLCASIEGINRQVEPLDPPAGSAPGEHVFVKGYEKGQPDEE
LKPKKKVFEKLQADFKISEECIAQWKQTNFMTKLGSISCKSLKGGNIS

BDBM50091497

n/a

Name

BDBM50091497

Synonyms:

(S)-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-((2S,3S,4S,5S)-1,3,4,5-tetrahydroxy-piperidin-2-yl)-acetic acid | CHEMBL51499 | [2-Amino-3-((S)-4-hydroxy-phenyl)-propionylamino]-((2S,3S,4S,5S)-1,3,4,5-tetrahydroxy-piperidin-2-yl)-acetic acid

Type

Small organic molecule

Emp. Form.

C16H23N3O8

Mol. Mass.

385.3691

SMILES

N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H]([C@H]1[C@H](O)[C@@H](O)[C@@H](O)CN1O)C(O)=O

Structure