| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine--tRNA ligase, cytoplasmic |
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| Ligand | BDBM50097749 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_211024 |
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| IC50 | 0.800000±n/a nM |
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| Citation |  Jarvest, RL; Berge, JM; Brown, P; Hamprecht, DW; McNair, DJ; Mensah, L; O'Hanlon, PJ; Pope, AJ Potent synthetic inhibitors of tyrosyl tRNA synthetase derived from C-pyranosyl analogues of SB-219383. Bioorg Med Chem Lett11:715-8 (2001) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosine--tRNA ligase, cytoplasmic |
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| Name: | Tyrosine--tRNA ligase, cytoplasmic |
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| Synonyms: | SYYC_HUMAN | Tyrosyl-tRNA synthetase | YARS | YARS1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 59145.78 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_211030 |
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| Residue: | 528 |
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| Sequence: | MGDAPSPEEKLHLITRNLQEVLGEEKLKEILKERELKIYWGTATTGKPHVAYFVPMSKIA
DFLKAGCEVTILFADLHAYLDNMKAPWELLELRVSYYENVIKAMLESIGVPLEKLKFIKG
TDYQLSKEYTLDVYRLSSVVTQHDSKKAGAEVVKQVEHPLLSGLLYPGLQALDEEYLKVD
AQFGGIDQRKIFTFAEKYLPALGYSKRVHLMNPMVPGLTGSKMSSSEEESKIDLLDRKED
VKKKLKKAFCEPGNVENNGVLSFIKHVLFPLKSEFVILRDEKWGGNKTYTAYVDLEKDFA
AEVVHPGDLKNSVEVALNKLLDPIREKFNTPALKKLASAAYPDPSKQKPMAKGPAKNSEP
EEVIPSRLDIRVGKIITVEKHPDADSLYVEKIDVGEAEPRTVVSGLVQFVPKEELQDRLV
VVLCNLKPQKMRGVESQGMLLCASIEGINRQVEPLDPPAGSAPGEHVFVKGYEKGQPDEE
LKPKKKVFEKLQADFKISEECIAQWKQTNFMTKLGSISCKSLKGGNIS
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| BDBM50097749 |
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| n/a |
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| Name | BDBM50097749 |
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| Synonyms: | CHEMBL163375 | [2-Amino-3-((S)-4-hydroxy-phenyl)-propionylamino]-((2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-methyl-tetrahydro-pyran-2-yl)-acetic acid (S)-butyl ester |
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| Type | Small organic molecule |
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| Emp. Form. | C21H32N2O8 |
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| Mol. Mass. | 440.4874 |
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| SMILES | CCCCOC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)[C@@H]1O[C@H](C)[C@H](O)[C@H](O)[C@H]1O |
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| Structure | 
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