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TargetCoagulation factor X
LigandBDBM50097756
Substrate/Competitorn/a
Meas. Tech.ChEBML_69661
Ki 42±n/a nM
Citation Jones SDLiebeschuetz JWMorgan PJMurray CWRimmer ADRoscoe JMWaszkowycz BWelsh PMWylie WAYoung SCMartin HMahler JBrady LWilkinson K The design of phenylglycine containing benzamidine carboxamides as potent and selective inhibitors of factor Xa. Bioorg Med Chem Lett 11:733-6 (2001) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Coagulation factor X
Name:Thrombin and coagulation factor X
Synonyms:Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor
Type:Enzyme
Mol. Mass.:54726.60
Organism:Homo sapiens (Human)
Description:n/a
Residue:488
Sequence:
MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEE
TCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKN
CELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERR
KRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQE
CKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGE
AVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGI
VSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSG
GPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPE
VITSSPLK
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50097756
n/a
NameBDBM50097756
Synonyms:3-Carbamimidoyl-N-[(R)-(4-methyl-benzylcarbamoyl)-phenyl-methyl]-benzamide | CHEMBL352144
TypeSmall organic molecule
Emp. Form.C24H24N4O2
Mol. Mass.400.473
SMILESCc1ccc(CNC(=O)[C@H](NC(=O)c2cccc(c2)C(N)=N)c2ccccc2)cc1
Structure
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