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TargetMicrosomal triglyceride transfer protein large subunit
LigandBDBM50098324
Substrate/Competitorn/a
Meas. Tech.ChEMBL_103133 (CHEMBL712303)
IC50 0.15±n/a nM
Citation Robl, JASulsky, RSun, CQSimpkins, LMWang, TDickson, JKChen, YMagnin, DRTaunk, PSlusarchyk, WABiller, SALan, SJConnolly, FKunselman, LKSabrah, TJamil, HGordon, DHarrity, TWWetterau, JR A novel series of highly potent benzimidazole-based microsomal triglyceride transfer protein inhibitors. J Med Chem44:851-6 (2001) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Microsomal triglyceride transfer protein large subunit
Name:Microsomal triglyceride transfer protein large subunit
Synonyms:MTP | MTP_HUMAN | MTTP | Microsomal triglyceride transfer protein | Microsomal triglyceride transfer protein large subunit
Type:PROTEIN
Mol. Mass.:99365.65
Organism:Homo sapiens (Human)
Description:ChEMBL_971724
Residue:894
Sequence:
MILLAVLFLCFISSYSASVKGHTTGLSLNNDRLYKLTYSTEVLLDRGKGKLQDSVGYRIS
SNVDVALLWRNPDGDDDQLIQITMKDVNVENVNQQRGEKSIFKGKSPSKIMGKENLEALQ
RPTLLHLIHGKVKEFYSYQNEAVAIENIKRGLASLFQTQLSSGTTNEVDISGNCKVTYQA
HQDKVIKIKALDSCKIARSGFTTPNQVLGVSSKATSVTTYKIEDSFVIAVLAEETHNFGL
NFLQTIKGKIVSKQKLELKTTEAGPRLMSGKQAAAIIKAVDSKYTAIPIVGQVFQSHCKG
CPSLSELWRSTRKYLQPDNLSKAEAVRNFLAFIQHLRTAKKEEILQILKMENKEVLPQLV
DAVTSAQTSDSLEAILDFLDFKSDSSIILQERFLYACGFASHPNEELLRALISKFKGSIG
SSDIRETVMIITGTLVRKLCQNEGCKLKAVVEAKKLILGGLEKAEKKEDTRMYLLALKNA
LLPEGIPSLLKYAEAGEGPISHLATTALQRYDLPFITDEVKKTLNRIYHQNRKVHEKTVR
TAAAAIILNNNPSYMDVKNILLSIGELPQEMNKYMLAIVQDILRFEMPASKIVRRVLKEM
VAHNYDRFSRSGSSSAYTGYIERSPRSASTYSLDILYSGSGILRRSNLNIFQYIGKAGLH
GSQVVIEAQGLEALIAATPDEGEENLDSYAGMSAILFDVQLRPVTFFNGYSDLMSKMLSA
SGDPISVVKGLILLIDHSQELQLQSGLKANIEVQGGLAIDISGAMEFSLWYRESKTRVKN
RVTVVITTDITVDSSFVKAGLETSTETEAGLEFISTVQFSQYPFLVCMQMDKDEAPFRQF
EKKYERLSTGRGYVSQKRKESVLAGCEFPLHQENSEMCKVVFAPQPDSTSSGWF
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  Blast E-value cutoff:
BDBM50098324
n/a
NameBDBM50098324
Synonyms:9-(4-{2-Methyl-4-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-benzoimidazol-1-yl}-butyl)-9H-fluorene-9-carboxylic acid (2,2,2-trifluoro-ethyl)-amide | CHEMBL168216
TypeSmall organic molecule
Emp. Form.C42H34F6N4O2
Mol. Mass.740.7354
SMILESCc1nc2c(NC(=O)c3ccccc3-c3ccc(cc3)C(F)(F)F)cccc2n1CCCCC1(C(=O)NCC(F)(F)F)c2ccccc2-c2ccccc12
Structure
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