Reaction Details |
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Target | Gonadotropin-releasing hormone receptor |
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Ligand | BDBM50098391 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_71446 (CHEMBL685318) |
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IC50 | 350±n/a nM |
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Citation | DeVita, RJ; Walsh, TF; Young, JR; Jiang, J; Ujjainwalla, F; Toupence, RB; Parikh, M; Huang, SX; Fair, JA; Goulet, MT; Wyvratt, MJ; Lo, JL; Ren, N; Yudkovitz, JB; Yang, YT; Cheng, K; Cui, J; Mount, G; Rohrer, SP; Schaeffer, JM; Rhodes, L; Drisko, JE; McGowan, E; MacIntyre, DE; Vincent, S; Carlin, JR; Cameron, J; Smith, RG A potent, nonpeptidyl 1H-quinolone antagonist for the gonadotropin-releasing hormone receptor. J Med Chem44:917-22 (2001) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Gonadotropin-releasing hormone receptor |
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Name: | Gonadotropin-releasing hormone receptor |
Synonyms: | GNRHR | GNRHR_HUMAN | GRHR | GnRH receptor | GnRH-R | Gonadotropin releasing hormone 1 (GnRHR1) | Gonadotropin-releasing hormone receptor | Gonadotropin-releasing hormone receptor (GnRH) |
Type: | Enzyme |
Mol. Mass.: | 37749.45 |
Organism: | Homo sapiens (Human) |
Description: | P30968 |
Residue: | 328 |
Sequence: | MANSASPEQNQNHCSAINNSIPLMQGNLPTLTLSGKIRVTVTFFLFLLSATFNASFLLKL
QKWTQKKEKGKKLSRMKLLLKHLTLANLLETLIVMPLDGMWNITVQWYAGELLCKVLSYL
KLFSMYAPAFMMVVISLDRSLAITRPLALKSNSKVGQSMVGLAWILSSVFAGPQLYIFRM
IHLADSSGQTKVFSQCVTHCSFSQWWHQAFYNFFTFSCLFIIPLFIMLICNAKIIFTLTR
VLHQDPHELQLNQSKNNIPRARLKTLKMTVAFATSFTVCWTPYYVLGIWYWFDPEMLNRL
SDPVNHFFFLFAFLNPCFDPLIYGYFSL
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BDBM50098391 |
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n/a |
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Name | BDBM50098391 |
Synonyms: | (S)-4-(2-(azetidin-2-yl)ethoxy)-7-chloro-2-oxo-N-(pyrimidin-4-yl)-3-(3,4,5-trimethylphenyl)-1,2-dihydroquinoline-6-carboxamide | 4-((S)-2-Azetidin-2-yl-ethoxy)-7-chloro-2-oxo-3-(3,4,5-trimethyl-phenyl)-1,2-dihydro-quinoline-6-carboxylic acid pyrimidin-4-ylamide | 4-(2-Azetidin-2-yl-ethoxy)-7-chloro-2-oxo-3-(3,4,5-trimethyl-phenyl)-1,2-dihydro-quinoline-6-carboxylic acid pyrimidin-4-ylamide | CHEMBL120432 |
Type | Small organic molecule |
Emp. Form. | C28H28ClN5O3 |
Mol. Mass. | 518.007 |
SMILES | Cc1cc(cc(C)c1C)-c1c(OCC[C@@H]2CCN2)c2cc(C(=O)Nc3ccncn3)c(Cl)cc2[nH]c1=O |r| |
Structure |
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