| Reaction Details |
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 | Report a problem with these data |
| Target | Gonadotropin-releasing hormone receptor |
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| Ligand | BDBM50098391 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_71733 (CHEMBL680412) |
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| IC50 | 81±n/a nM |
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| Citation |  DeVita, RJ; Walsh, TF; Young, JR; Jiang, J; Ujjainwalla, F; Toupence, RB; Parikh, M; Huang, SX; Fair, JA; Goulet, MT; Wyvratt, MJ; Lo, JL; Ren, N; Yudkovitz, JB; Yang, YT; Cheng, K; Cui, J; Mount, G; Rohrer, SP; Schaeffer, JM; Rhodes, L; Drisko, JE; McGowan, E; MacIntyre, DE; Vincent, S; Carlin, JR; Cameron, J; Smith, RG A potent, nonpeptidyl 1H-quinolone antagonist for the gonadotropin-releasing hormone receptor. J Med Chem44:917-22 (2001) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Gonadotropin-releasing hormone receptor |
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| Name: | Gonadotropin-releasing hormone receptor |
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| Synonyms: | GNRHR_RAT | GnRH receptor | GnRH-R | Gnrhr |
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| Type: | PROTEIN |
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| Mol. Mass.: | 37767.60 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_1335047 |
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| Residue: | 327 |
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| Sequence: | MANNASLEQDQNHCSAINNSIPLTQGKLPTLTLSGKIRVTVTFFLFLLSTAFNASFLVKL
QRWTQKRKKGKKLSRMKVLLKHLTLANLLETLIVMPLDGMWNITVQWYAGEFLCKVLSYL
KLFSMYAPAFMMVVISLDRSLAVTQPLAVQSKSKLERSMTSLAWILSIVFAGPQLYIFRM
IYLADGSGPAVFSQCVTHCSFPQWWHEAFYNFFTFSCLFIIPLLIMLICNAKIIFALTRV
LHQDPRKLQLNQSKNNIPRARLRTLKMTVAFGTSFVICWTPYYVLGIWYWFDPEMLNRVS
EPVNHFFFLFAFLNPCFDPLIYGYFSL
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| BDBM50098391 |
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| n/a |
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| Name | BDBM50098391 |
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| Synonyms: | (S)-4-(2-(azetidin-2-yl)ethoxy)-7-chloro-2-oxo-N-(pyrimidin-4-yl)-3-(3,4,5-trimethylphenyl)-1,2-dihydroquinoline-6-carboxamide | 4-((S)-2-Azetidin-2-yl-ethoxy)-7-chloro-2-oxo-3-(3,4,5-trimethyl-phenyl)-1,2-dihydro-quinoline-6-carboxylic acid pyrimidin-4-ylamide | 4-(2-Azetidin-2-yl-ethoxy)-7-chloro-2-oxo-3-(3,4,5-trimethyl-phenyl)-1,2-dihydro-quinoline-6-carboxylic acid pyrimidin-4-ylamide | CHEMBL120432 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H28ClN5O3 |
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| Mol. Mass. | 518.007 |
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| SMILES | Cc1cc(cc(C)c1C)-c1c(OCC[C@@H]2CCN2)c2cc(C(=O)Nc3ccncn3)c(Cl)cc2[nH]c1=O |r| |
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| Structure | 
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