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TargetIntercellular adhesion molecule (ICAM-1), Integrin alpha-L/beta-2
LigandBDBM50098517
Substrate/Competitorn/a
Meas. Tech.ChEMBL_89064
IC50 8±n/a nM
Citation Stewart AOBhatia PAMcCarty CMPatel MVStaeger MAArendsen DLGunawardana IWMelcher LMZhu GDBoyd SAFry DGCool BLKifle LLartey KMarsh KCKempf-Grote AJKilgannon PWisdom WMeyer JGallatin WMOkasinski GF Discovery of inhibitors of cell adhesion molecule expression in human endothelial cells. 1. Selective inhibition of ICAM-1 and E-selectin expression. J Med Chem 44:988-1002 (2001) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Intercellular adhesion molecule (ICAM-1), Integrin alpha-L/beta-2
Name:Intercellular adhesion molecule (ICAM-1), Integrin alpha-L/beta-2
Synonyms:CD_antigen=CD54 | ICAM-1 | Intercellular adhesion molecule 1 | Intercellular adhesion molecule-1 | Major group rhinovirus receptor
Type:PROTEIN
Mol. Mass.:57831.10
Organism:Homo sapiens (Human)
Description:ChEMBL_826675
Residue:532
Sequence:
MAPSSPRPALPALLVLLGALFPGPGNAQTSVSPSKVILPRGGSVLVTCSTSCDQPKLLGI
ETPLPKKELLLPGNNRKVYELSNVQEDSQPMCYSNCPDGQSTAKTFLTVYWTPERVELAP
LPSWQPVGKNLTLRCQVEGGAPRANLTVVLLRGEKELKREPAVGEPAEVTTTVLVRRDHH
GANFSCRTELDLRPQGLELFENTSAPYQLQTFVLPATPPQLVSPRVLEVDTQGTVVCSLD
GLFPVSEAQVHLALGDQRLNPTVTYGNDSFSAKASVSVTAEDEGTQRLTCAVILGNQSQE
TLQTVTIYSFPAPNVILTKPEVSEGTEVTVKCEAHPRAKVTLNGVPAQPLGPRAQLLLKA
TPEDNGRSFSCSATLEVAGQLIHKNQTRELRVLYGPRLDERDCPGNWTWPENSQQTPMCQ
AWGNPLPELKCLKDGTFPLPIGESVTVTRDLEGTYLCRARSTQGEVTRKVTVNVLSPRYE
IVIITVVAAAVIMGTAGLSTYLYNRQRKIKKYRLQQAQKGTPMKPNTQATPP
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50098517
n/a
NameBDBM50098517
Synonyms:4-(3,4-Dimethyl-phenylsulfanyl)-thieno[2,3-c]pyridine-2-carboxylic acid amide | CHEMBL267125
TypeSmall organic molecule
Emp. Form.C16H14N2OS2
Mol. Mass.314.425
SMILESCc1ccc(Sc2cncc3sc(cc23)C(N)=O)cc1C
Structure
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