Reaction Details |
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Target | 5-hydroxytryptamine receptor 2A |
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Ligand | BDBM50098527 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2621 (CHEMBL621533) |
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Ki | 0.7±n/a nM |
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Citation | Chambers, JJ; Kurrasch-Orbaugh, DM; Parker, MA; Nichols, DE Enantiospecific synthesis and pharmacological evaluation of a series of super-potent, conformationally restricted 5-HT(2A/2C) receptor agonists. J Med Chem44:1003-10 (2001) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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5-hydroxytryptamine receptor 2A |
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Name: | 5-hydroxytryptamine receptor 2A |
Synonyms: | 5-HT-2A | 5-HT2 | 5-HT2A | 5-hydroxytryptamine receptor 2A (5-HT2A) | 5-hydroxytryptamine receptor 2A (5HT2A) | 5HT2A_RAT | Htr2 | Htr2a | Serotonin Receptor 2A |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 52852.05 |
Organism: | Rattus norvegicus (rat) |
Description: | Rat cortex membranes 5-HT2A receptors. |
Residue: | 471 |
Sequence: | MEILCEDNISLSSIPNSLMQLGDGPRLYHNDFNSRDANTSEASNWTIDAENRTNLSCEGY
LPPTCLSILHLQEKNWSALLTTVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIAD
MLLGFLVMPVSMLTILYGYRWPLPSKLCAIWIYLDVLFSTASIMHLCAISLDRYVAIQNP
IHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSF
VAFFIPLTIMVITYFLTIKSLQKEATLCVSDLSTRAKLASFSFLPQSSLSSEKLFQRSIH
REPGSYAGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNENVIGA
LLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENRKPLQLILVNTIPALAYK
SSQLQVGQKKNSQEDAEQTVDDCSMVTLGKQQSEENCTDNIETVNEKVSCV
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BDBM50098527 |
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n/a |
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Name | BDBM50098527 |
Synonyms: | 1-Methyl-2-(8-trifluoromethyl-2,3,6,7-tetrahydro-benzo[1,2-b;4,5-b']difuran-4-yl)-ethyl-ammonium; chloride | CHEMBL6452 |
Type | Small organic molecule |
Emp. Form. | C14H17F3NO2 |
Mol. Mass. | 288.2849 |
SMILES | C[C@@H]([NH3+])Cc1c2CCOc2c(c2CCOc12)C(F)(F)F |
Structure |
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