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TargetCathepsin K
LigandBDBM50098582
Substrate/Competitorn/a
Meas. Tech.ChEMBL_216705 (CHEMBL820317)
Ki 30±n/a nM
Citation Marquis, RWRu, YLoCastro, SMZeng, JYamashita, DSOh, HJErhard, KFDavis, LDTomaszek, TATew, DSalyers, KProksch, JWard, KSmith, BLevy, MCummings, MDHaltiwanger, RCTrescher, GWang, BHemling, MEQuinn, CJCheng, HYLin, FSmith, WWJanson, CAZhao, BMcQueney, MSD'Alessio, KLee, CPMarzulli, ADodds, RABlake, SHwang, SMJames, IEGress, CJBradley, BRLark, MWGowen, MVeber, DF Azepanone-based inhibitors of human and rat cathepsin K. J Med Chem44:1380-95 (2001) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Cathepsin K
Name:Cathepsin K
Synonyms:CATK_HUMAN | CTSK | CTSO | CTSO2 | Cathepsin O | Cathepsin O2 | Cathepsin X
Type:Enzyme
Mol. Mass.:36975.68
Organism:Homo sapiens (Human)
Description:P43235
Residue:329
Sequence:
MWGLKVLLLPVVSFALYPEEILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYISIH
NLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPLSHSRSNDTLYIPEWEGRAPDSVD
YRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGG
YMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAVA
RVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGE
NWGNKGYILMARNKNNACGIANLASFPKM
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50098582
n/a
NameBDBM50098582
Synonyms:CHEMBL31519 | {1-[4-(2-Benzyloxycarbonylamino-4-methyl-pentanoylamino)-3-oxo-azepane-1-carbonyl]-3-methyl-butyl}-carbamic acid benzyl ester
TypeSmall organic molecule
Emp. Form.C34H46N4O7
Mol. Mass.622.7516
SMILESCC(C)C[C@@H](NC(=O)OCc1ccccc1)C(=O)NC1CCCN(CC1=O)C(=O)[C@H](CC(C)C)NC(=O)OCc1ccccc1
Structure
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